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Review

Management of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Pitfalls and Caveat

by
Francesco Perri
1,*,
Francesco Longo
2,
Francesco Caponigro
1,
Fabio Sandomenico
3,
Agostino Guida
2,
Giuseppina Della Vittoria Scarpati
4,
Alessandro Ottaiano
5,
Paolo Muto
6 and
Franco Ionna
2
1
Head and Neck Medical Oncology Unit, Istituto Nazionale Tumori, IRCCS G. Pascale, 80131 Naples, Italy
2
Division of Surgical Oncology Maxillo-Facial Unit, Istituto Nazionale Tumori—IRCCS—Fondazione G. Pascale, Via Mariano Semmola, 80131 Naples, Italy
3
Unit, Istituto Nazionale Tumori—IRCCS—G. Pascale, 80131 Naples, Italy
4
Medical Oncology Unit, Ospedale Pollena, ASL NA3, 80040 Naples, Italy
5
SSD Innovative Therapies for Abdominal Metastases, Department of Abdominal Oncology, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy
6
Radiation Oncology Unit, Istituto Nazionale Tumori—IRCCS—G. Pascale, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(4), 975; https://doi.org/10.3390/cancers12040975
Submission received: 13 March 2020 / Revised: 8 April 2020 / Accepted: 10 April 2020 / Published: 15 April 2020
(This article belongs to the Special Issue Human Papillomavirus and Cancers)
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Abstract

Head and neck squamous cell carcinomas (HNSCCs) are a very heterogeneous group of malignancies arising from the upper aerodigestive tract. They show different clinical behaviors depending on their origin site and genetics. Several data support the existence of at least two genetically different types of HNSCC, one virus-related and the other alcohol and/or tobacco and oral trauma-related, which show both clinical and biological opposite features. In fact, human papillomavirus (HPV)-related HNSCCs, which are mainly located in the oropharynx, are characterized by better prognosis and response to therapies when compared to HPV-negative HNSCCs. Interestingly, virus-related HNSCC has shown a better response to conservative (nonsurgical) treatments and immunotherapy, opening questions about the possibility to perform a pretherapy assessment which could totally guide the treatment strategy. In this review, we summarize molecular differences and similarities between HPV-positive and HPV-negative HNSCC, highlighting their impact on clinical behavior and on therapeutic strategies.
Keywords: human papilloma virus; squamous cell carcinoma of the head and neck; translational research; oncogenes; tumor suppressor genes human papilloma virus; squamous cell carcinoma of the head and neck; translational research; oncogenes; tumor suppressor genes

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MDPI and ACS Style

Perri, F.; Longo, F.; Caponigro, F.; Sandomenico, F.; Guida, A.; Della Vittoria Scarpati, G.; Ottaiano, A.; Muto, P.; Ionna, F. Management of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Pitfalls and Caveat. Cancers 2020, 12, 975. https://doi.org/10.3390/cancers12040975

AMA Style

Perri F, Longo F, Caponigro F, Sandomenico F, Guida A, Della Vittoria Scarpati G, Ottaiano A, Muto P, Ionna F. Management of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Pitfalls and Caveat. Cancers. 2020; 12(4):975. https://doi.org/10.3390/cancers12040975

Chicago/Turabian Style

Perri, Francesco, Francesco Longo, Francesco Caponigro, Fabio Sandomenico, Agostino Guida, Giuseppina Della Vittoria Scarpati, Alessandro Ottaiano, Paolo Muto, and Franco Ionna. 2020. "Management of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Pitfalls and Caveat" Cancers 12, no. 4: 975. https://doi.org/10.3390/cancers12040975

APA Style

Perri, F., Longo, F., Caponigro, F., Sandomenico, F., Guida, A., Della Vittoria Scarpati, G., Ottaiano, A., Muto, P., & Ionna, F. (2020). Management of HPV-Related Squamous Cell Carcinoma of the Head and Neck: Pitfalls and Caveat. Cancers, 12(4), 975. https://doi.org/10.3390/cancers12040975

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