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Open AccessArticle

An Integrated Portable Multiplex Microchip Device for Fingerprinting Chemical Warfare Agents

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CSIRO Manufacturing, Bayview Ave, Clayton 3168, Australia
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DST, 506 Lorimer Street, Fishermans Bend, VIC 3207, Australia
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Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China
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School of Science, RMIT University, Melbourne, VIC 3001, Australia
*
Author to whom correspondence should be addressed.
Micromachines 2019, 10(9), 617; https://doi.org/10.3390/mi10090617
Received: 27 July 2019 / Revised: 9 September 2019 / Accepted: 11 September 2019 / Published: 16 September 2019
(This article belongs to the Special Issue IMCO 2019)
The rapid and reliable detection of chemical and biological agents in the field is important for many applications such as national security, environmental monitoring, infectious diseases screening, and so on. Current commercially available devices may suffer from low field deployability, specificity, and reproducibility, as well as a high false alarm rate. This paper reports the development of a portable lab-on-a-chip device that could address these issues. The device integrates a polymer multiplexed microchip system, a contactless conductivity detector, a data acquisition and signal processing system, and a graphic/user interface. The samples are pre-treated by an on-chip capillary electrophoresis system. The separated analytes are detected by conductivity-based microsensors. Extensive studies are carried out to achieve satisfactory reproducibility of the microchip system. Chemical warfare agents soman (GD), sarin (GB), O-ethyl S-[2-diisoproylaminoethyl] methylphsophonothioate (VX), and their degradation products have been tested on the device. It was demonstrated that the device can fingerprint the tested chemical warfare agents. In addition, the detection of ricin and metal ions in water samples was demonstrated. Such a device could be used for the rapid and sensitive on-site detection of both chemical and biological agents in the future. View Full-Text
Keywords: lab on a chip; chemical warfare agent; conductivity sensor; microchip capillary electrophoresis lab on a chip; chemical warfare agent; conductivity sensor; microchip capillary electrophoresis
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MDPI and ACS Style

Petkovic, K.; Swallow, A.; Stewart, R.; Gao, Y.; Li, S.; Glenn, F.; Gotama, J.; Dell’Olio, M.; Best, M.; Doward, J.; Ovendon, S.; Zhu, Y. An Integrated Portable Multiplex Microchip Device for Fingerprinting Chemical Warfare Agents. Micromachines 2019, 10, 617.

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