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Toxins 2016, 8(2), 53;

Insight into the Mode of Action of Haedoxan A from Phryma leptostachya

Institute of Pesticide Science, College of Plant Protection, Northwest A & F University, Yangling 712100, Shaanxi, China
Key Laboratory of Botanical Pesticide R & D in Shaanxi Province, Yangling 712100, Shaanxi, China
Department of Entomology, Michigan State University, East Lansing, MI 48824, USA
These two authors contribute equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 12 December 2015 / Revised: 14 February 2016 / Accepted: 15 February 2016 / Published: 22 February 2016
(This article belongs to the Section Plant Toxins)
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Haedoxan A (HA) is a major active ingredient in the herbaceous perennial plant lopseed (Phryma leptostachya L.), which is used as a natural insecticide against insect pests in East Asia. Here, we report that HA delayed the decay rate of evoked excitatory junctional potentials (EJPs) and increased the frequency of miniature EJPs (mEJPs) on the Drosophila neuromuscular junction. HA also caused a significant hyperpolarizing shift of the voltage dependence of fast inactivation of insect sodium channels expressed in Xenopus oocytes. Our results suggest that HA acts on both axonal conduction and synaptic transmission, which can serve as a basis for elucidating the mode of action of HA for further designing and developing new effective insecticides. View Full-Text
Keywords: botanical insecticides; haedoxan A (HA); synaptic transmission; voltage-gated sodium channel botanical insecticides; haedoxan A (HA); synaptic transmission; voltage-gated sodium channel

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Hu, Z.; Du, Y.; Xiao, X.; Dong, K.; Wu, W. Insight into the Mode of Action of Haedoxan A from Phryma leptostachya. Toxins 2016, 8, 53.

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