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Open AccessArticle

Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats

by 1,2,†,‡, 1,2,*,†, 2,3 and 1,2,†
1
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, University of Navarra, CIFA Building, c/Irunlarrea 1, E-31008 Pamplona, Spain
2
IdiSNA, Navarra Institute for Health Research, E-31008 Pamplona, Spain
3
Bioinformatics Platform, Center for Applied Medical Research (CIMA), University of Navarra, E-31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Current address: General Mills, 31570 San Adrián, Navarra, Spain.
Toxins 2021, 13(3), 177; https://doi.org/10.3390/toxins13030177
Received: 26 January 2021 / Revised: 16 February 2021 / Accepted: 20 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Mycotoxins and Its Gene Regulation)
The mycotoxin ochratoxin A (OTA) is a potent nephrocarcinogen, mainly in male rats. The aim of this study was to determine the time course of gene expression (GeneChip® Rat Gene 2.0 ST Array, Affymetrix) in kidney samples from male and female F344 rats, treated daily (p.o) with 0.50 mg/kg b.w. (body weight) of OTA for 7 or 21 days, and evaluate if there were differences between both sexes. After OTA treatment, there was an evolution of gene expression in the kidney over time, with more differentially expressed genes (DEG) at 21 days. The gene expression time course was different between sexes with respect to the number of DEG and the direction of expression (up or down): the female response was progressive and consistent over time, whereas males had a different early response with more DEG, most of them up-regulated. The statistically most significant DEG corresponded to metabolism enzymes (Akr1b7, Akr1c2, Adh6 down-regulated in females; Cyp2c11, Dhrs7, Cyp2d1, Cyp2d5 down-regulated in males) or transporters (Slc17a9 down-regulated in females; Slco1a1 (OATP-1) and Slc51b and Slc22a22 (OAT) down-regulated in males). Some of these genes had also a basal sex difference and were over-expressed in males or females with respect to the other sex. View Full-Text
Keywords: ochratoxin A (OTA); sex differences; gene expression; metabolism; transporters; Fisher rats ochratoxin A (OTA); sex differences; gene expression; metabolism; transporters; Fisher rats
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MDPI and ACS Style

Pastor, L.; Vettorazzi, A.; Guruceaga, E.; López de Cerain, A. Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats. Toxins 2021, 13, 177. https://doi.org/10.3390/toxins13030177

AMA Style

Pastor L, Vettorazzi A, Guruceaga E, López de Cerain A. Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats. Toxins. 2021; 13(3):177. https://doi.org/10.3390/toxins13030177

Chicago/Turabian Style

Pastor, Laura; Vettorazzi, Ariane; Guruceaga, Elizabeth; López de Cerain, Adela. 2021. "Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats" Toxins 13, no. 3: 177. https://doi.org/10.3390/toxins13030177

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