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Supplement Timing of Cranberry Extract Plays a Key Role in Promoting Caenorhabditis elegans Healthspan

1
Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA
2
Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA
3
Functional Genomics Unit, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2014, 6(2), 911-921; https://doi.org/10.3390/nu6020911
Received: 25 November 2013 / Revised: 20 December 2013 / Accepted: 11 February 2014 / Published: 21 February 2014
Consumption of nutraceuticals is a major and potent dietary intervention for delaying aging. As the timing of administration is critical for the efficacy of bioactive compounds in medicine, the effectiveness of nutraceuticals may also be dramatically affected by the timing of supplementation. Cranberry exact (CBE), rich in polyphenols, is consumed as a nutraceutical, and possesses anti-aging properties. Here, we examined the influence of timing on the beneficial effects of CBE supplementation in C. elegans. The prolongevity effect of CBE in different aged worms, young adults, middle-age adults, and aged adults, was determined. Early-start intervention with CBE prolonged the remaining lifespan of worms of different ages more robustly than late-start intervention. The effectiveness of CBE on stress responses and physiological behaviors in different aged worms was also investigated. The early-start intervention prominently promoted motility and resistance to heat shocks and V. cholera infection, especially in aged worms. Together, these findings suggest that the timing of CBE supplementation critically influences its beneficial effects on C. elegans lifespan and healthspan. It is of interest to further investigate whether the similar results would occur in humans. View Full-Text
Keywords: aging intervention; timing; nutraceuticals; cranberry polyphenols; healthspan; Caenorhabditis elegans aging intervention; timing; nutraceuticals; cranberry polyphenols; healthspan; Caenorhabditis elegans
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Guha, S.; Natarajan, O.; Murbach, C.G.; Dinh, J.; Wilson, E.C.; Cao, M.; Zou, S.; Dong, Y. Supplement Timing of Cranberry Extract Plays a Key Role in Promoting Caenorhabditis elegans Healthspan. Nutrients 2014, 6, 911-921.

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