Deceptive Caffeine Shows Limited Impact on Short-Term Neuromuscular Performance
Abstract
1. Introduction
2. Materials and Methods
2.1. Design
2.2. Participants
2.3. Procedures
2.4. Data Analysis
3. Results
3.1. Jump Performance
3.2. Bench Press Throws at 25–50–75% of 1RM
3.3. Side Effects
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Colloca, L.; Barsky, A.J. Placebo and Nocebo Effects. N. Engl. J. Med. 2020, 382, 554–561. [Google Scholar] [CrossRef] [PubMed]
- Pollo, A.; Carlino, E.; Benedetti, F. Placebo mechanisms across different conditions: From the clinical setting to physical performance. Philos. Trans. R. Soc. B Biol. Sci. 2011, 366, 1790–1798. [Google Scholar] [CrossRef] [PubMed]
- Beedie, C.; Benedetti, F.; Barbiani, D.; Camerone, E.; Cohen, E.; Coleman, D.; Davis, A.; Elsworth-Edelsten, C.; Flowers, E.; Foad, A.; et al. Consensus statement on placebo effects in sports and exercise: The need for conceptual clarity, methodological rigour, and the elucidation of neurobiological mechanisms. Eur. J. Sport Sci. 2018, 18, 1383–1389. [Google Scholar] [CrossRef] [PubMed]
- Frisaldi, E.; Piedimonte, A.; Benedetti, F. Placebo and nocebo effects: A complex interplay between psychological factors and neurochemical networks. Am. J. Clin. Hypn. 2015, 57, 267–284. [Google Scholar] [CrossRef]
- Frisaldi, E.; Shaibani, A.; Benedetti, F. Understanding the mechanisms of placebo and nocebo effects. Swiss Med. Wkly. 2020, 150, 20340. [Google Scholar] [CrossRef]
- Frisaldi, E.; Shaibani, A.; Benedetti, F.; Pagnini, F. Placebo and nocebo effects and mechanisms associated with pharmacological interventions: An umbrella review. BMJ Open 2023, 13, e077243. [Google Scholar] [CrossRef]
- Hurst, P.; Schipof-Godart, L.; Szabo, A.; Raglin, J.; Hettinga, F.; Roelands, B.; Lane, A.; Foad, A.; Coleman, D.; Beedie, C.J. The Placebo and Nocebo effect on sports performance: A systematic review. Eur. J. Sport Sci. 2020, 20, 279–292. [Google Scholar] [CrossRef]
- Chhabra, B.; Szabo, A. Placebo and Nocebo Effects on Sports and Exercise Performance: A Systematic Literature Review Update. Nutrients 2024, 16, 1975. [Google Scholar] [CrossRef]
- Beedie, C.J.; Stuart, E.M.; Coleman, D.A.; Foad, A.J. Placebo effects of caffeine on cycling performance. Med. Sci. Sports Exerc. 2006, 38, 2159–2164. [Google Scholar] [CrossRef]
- Beedie, C.J.; Coleman, D.A.; Foad, A.J.; Beedie, C.J.; Coleman, D.A.; Foad, A.J. Positive and Negative Placebo Effects Resulting from the Deceptive Administration of an Ergogenic Aid. Int. J. Sport Nutr. Exerc. Metab. 2007, 17, 259–269. [Google Scholar] [CrossRef]
- Campelo, D.; Koch, A.J.; Machado, M. Caffeine, lactic acid, or nothing: What effect does expectation have on men’s performance and perceived exertion during an upper body muscular endurance task? Int. J. Health Sci. 2023, 17, 39–42. [Google Scholar]
- Azevedo, P.H.; Oliveira, M.G.; Tanaka, K.; Pereira, P.E.; Esteves, G.; Tenan, M.S. Perceived exertion and performance modulation: Effects of caffeine ingestion and subject expectation. J. Sports Med. Phys. Fitness 2021, 61, 1185–1192. [Google Scholar] [CrossRef]
- Aguilar-Navarro, M.; Muñoz, G.; Salinero, J.J.; Muñoz-Guerra, J.; Fernández-álvarez, M.; Plata, M.D.M.; Del Coso, J. Urine Caffeine Concentration in Doping Control Samples from 2004 to 2015. Nutrients 2019, 11, 286. [Google Scholar] [CrossRef] [PubMed]
- Pickering, C.; Kiely, J. What Should We Do About Habitual Caffeine Use in Athletes? Sports Med. 2019, 49, 833–842. [Google Scholar] [CrossRef]
- Chester, N.; Wojek, N. Caffeine consumption amongst British athletes following changes to the 2004 WADA prohibited list. Int. J. Sports Med. 2008, 29, 524–528. [Google Scholar] [CrossRef] [PubMed]
- Guest, N.S.; VanDusseldorp, T.A.; Nelson, M.T.; Grgic, J.; Schoenfeld, B.J.; Jenkins, N.D.M.; Arent, S.M.; Antonio, J.; Stout, J.R.; Trexler, E.T.; et al. International society of sports nutrition position stand: Caffeine and exercise performance. J. Int. Soc. Sports Nutr. 2021, 18, 1. [Google Scholar] [CrossRef] [PubMed]
- Grgic, J.; Grgic, I.; Pickering, C.; Schoenfeld, B.J.; Bishop, D.J.; Pedisic, Z. Wake up and smell the coffee: Caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. Br. J. Sports Med. 2020, 54, 681–688. [Google Scholar] [CrossRef]
- Wang, Z.; Qiu, B.; Gao, J.; Del Coso, J. Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis. Nutrients 2022, 15, 148. [Google Scholar] [CrossRef]
- Grgic, J. Effects of Caffeine on Resistance Exercise: A Review of Recent Research. Sports Med. 2021, 51, 2281–2298. [Google Scholar] [CrossRef]
- Graham, T.E. Caffeine and Exercise. Sports Med. 2001, 31, 785–807. [Google Scholar] [CrossRef]
- Goldstein, E.R.; Ziegenfuss, T.; Kalman, D.; Kreider, R.; Campbell, B.; Wilborn, C.; Taylor, L.; Willoughby, D.; Stout, J.; Graves, B.S.; et al. International society of sports nutrition position stand: Caffeine and performance. J. Int. Soc. Sports Nutr. 2010, 7, 5. [Google Scholar] [CrossRef]
- Giraldez-Costas, V.; Del Coso, J.; Manas, A.; Salinero, J.J. The Long Way to Establish the Ergogenic Effect of Caffeine on Strength Performance: An Overview Review. Nutrients 2023, 15, 1178. [Google Scholar] [CrossRef]
- Grgic, J.; Mikulic, P. Effects of caffeine on rate of force development: A meta-analysis. Scand. J. Med. Sci. Sports 2021, 32, 644–653. [Google Scholar] [CrossRef]
- Raya-González, J.; Rendo-Urteaga, T.; Domínguez, R.; Castillo, D.; Rodríguez-Fernández, A.; Grgic, J. Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis. Sports Med. 2020, 50, 717–729. [Google Scholar] [CrossRef]
- Giráldez-Costas, V.; González-García, J.; Lara, B.; Coso, J.D.; Wilk, M.; Salinero, J.J. Caffeine Increases Muscle Performance during a Bench Press Training Session. J. Hum. Kinet. 2020, 74, 185–193. [Google Scholar] [CrossRef]
- Del Coso, J.; Salinero, J.J.; González-Millán, C.; Abián-Vicén, J.; Pérez-González, B. Dose response effects of a caffeine-containing energy drink on muscle performance: A repeated measures design. J. Int. Soc. Sports Nutr. 2012, 9, 21. [Google Scholar] [CrossRef] [PubMed]
- Ding, L.; Liu, J.; Yao, Y.; Guo, L.; Chen, B.; Cao, Y.; Girard, O. Caffeinated chewing gum enhances maximal strength and muscular endurance during bench press and back squat exercises in resistance-trained men. Front. Nutr. 2025, 12, 1540552. [Google Scholar] [CrossRef] [PubMed]
- Filip-Stachnik, A.; Krzysztofik, M.; Del Coso, J.; Wilk, M. Acute effects of two caffeine doses on bar velocity during the bench press exercise among women habituated to caffeine: A randomized, crossover, double-blind study involving control and placebo conditions. Eur. J. Nutr. 2022, 61, 947–955. [Google Scholar] [CrossRef] [PubMed]
- Scapec, B.; Grgic, J.; Varovic, D.; Mikulic, P. Caffeine, but not paracetamol (acetaminophen), enhances muscular endurance, strength, and power. J. Int. Soc. Sports Nutr. 2024, 21, 2400513. [Google Scholar] [CrossRef]
- Grgic, J.; Venier, S.; Mikulic, P. Both Caffeine and Placebo Improve Vertical Jump Performance Compared With a Nonsupplemented Control Condition. Int. J. Sports Physiol. Perform. 2021, 16, 448–451. [Google Scholar] [CrossRef]
- Del Coso, J.; Pérez-López, A.; Abian-Vicen, J.; Salinero, J.J.; Lara, B.; Valadés, D. Enhancing physical performance in male volleyball players with a caffeine-containing energy drink. Int. J. Sports Physiol. Perform. 2014, 9, 1013–1018. [Google Scholar] [CrossRef] [PubMed]
- Pérez-López, A.; Salinero, J.J.; Abian-Vicen, J.; Valadés, D.; Lara, B.; Hernandez, C.; Areces, F.; González, C.; Del Coso, J. Caffeinated energy drinks improve volleyball performance in elite female players. Med. Sci. Sports Exerc. 2015, 47, 850–856. [Google Scholar] [CrossRef]
- Salinero, J.J.; Lara, B.; Abian-Vicen, J.; Gonzalez-Millán, C.; Areces, F.; Gallo-Salazar, C.; Ruiz-Vicente, D.; Del Coso, J. The use of energy drinks in sport: Perceived ergogenicity and side effects in male and female athletes. Br. J. Nutr. 2014, 112, 1494–1502. [Google Scholar] [CrossRef]
- Pallarés, J.G.; Fernández-Elías, V.E.; Ortega, J.F.; Muñoz, G.; Muñoz-Guerra, J.; Mora-Rodríguez, R. Neuromuscular responses to incremental caffeine doses: Performance and side effects. Med. Sci. Sports Exerc. 2013, 45, 2184–2192. [Google Scholar] [CrossRef]
- de Souza, J.G.; Del Coso, J.; Fonseca, F.S.; Silva, B.V.C.; de Souza, D.B.; da Silva Gianoni, R.L.; Filip-Stachnik, A.; Serrao, J.C.; Claudino, J.G. Risk or benefit? Side effects of caffeine supplementation in sport: A systematic review. Eur. J. Nutr. 2022, 61, 3823–3834. [Google Scholar] [CrossRef]
- Cappelletti, S.; Piacentino, D.; Sani, G.; Aromatario, M. Caffeine: Cognitive and physical performance enhancer or psychoactive drug? Curr. Neuropharmacol. 2015, 13, 71–88. [Google Scholar] [CrossRef]
- Hurst, P.; Schipof-Godart, L.; Hettinga, F.; Roelands, B.; Beedie, C.J. Improved 1000-m Running Performance and Pacing Strategy With Caffeine and Placebo: A Balanced Placebo Design Study. Int. J. Sports Physiol. Perform. 2019, 15, 483–488. [Google Scholar] [CrossRef] [PubMed]
- Coso, J.; Lara, B.; Gallo-Salazar, C.; Areces, F.; Aguilar-Navarro, M.; Giráldez-Costas, V.; Gutiérrez-Hellín, J.; Valero, F.; Salinero, J.J. Exploring the potential synergistic pharmacological and psychological effects of caffeine on exercise performance: A placebo-balanced study. Biol. Sport 2026, 43, 95–105. [Google Scholar] [CrossRef]
- Agudo-Ortega, A.; Muñoz De La Cruz, V.; Valero, F.; Morallón, P.; González-Mohíno, F.; Salinero, J.J. The placebo effect does not enhance sprinting or jumping performance in trained athletes. J. Hum. Sport Exerc. 2025, 20, 787–797. [Google Scholar] [CrossRef]
- Costa, G.; Galvão, L.; Bottaro, M.; Mota, J.F.; Pimentel, G.D.; Gentil, P. Effects of placebo on bench throw performance of Paralympic weightlifting athletes: A pilot study. J. Int. Soc. Sports Nutr. 2019, 16, 9. [Google Scholar] [CrossRef]
- Ortiz-Sánchez, D.; Bravo-Sánchez, A.; Ramírez-delaCruz, M.; Abián, P.; Abián-Vicén, J.; Ortiz-Sánchez, D.; Bravo-Sánchez, A.; Ramírez-delaCruz, M.; Abián, P.; Abián-Vicén, J. Placebo Effect of Caffeine on Physiological Parameters and Physical Performance. Nutrients 2024, 16, 1405. [Google Scholar] [CrossRef]
- Szabo, A. Placebo doping in sport: Overview and ethical considerations. J. Sport Exerc. Sci. 2023, 7, 60–67. [Google Scholar] [CrossRef]
- Mayhew, J.L.; Prinster, J.L.; Ware, J.S.; Zimmer, D.L.; Arabas, J.R.; Bemben, M.G. Muscular endurance repetitions to predict bench press strength in men of different training levels. J. Sports Med. Phys. Fitness 1995, 35, 108–113. [Google Scholar]
- Del Val-Manzano, M.; Montalvo-Alonso, J.J.; Valades, D.; Ferragut, C.; Martin-Lopez, J.; Lopez-Samanes, A.; Perez-Lopez, A. Muscular strength and power and endurance performance at loads exceeding 25% of one-repetition maximum are unaffected by time-of-day in resistance-trained male participants. Chronobiol. Int. 2025, 42, 1039–1047. [Google Scholar] [CrossRef]
- Comyns, T.M.; Murphy, J.; O’Leary, D. Reliability, Usefulness, and Validity of Field-Based Vertical Jump Measuring Devices. J. Strength Cond. Res. 2023, 37, 1594–1599. [Google Scholar] [CrossRef] [PubMed]
- Perez-Castilla, A.; Piepoli, A.; Delgado-Garcia, G.; Garrido-Blanca, G.; Garcia-Ramos, A. Reliability and Concurrent Validity of Seven Commercially Available Devices for the Assessment of Movement Velocity at Different Intensities During the Bench Press. J. Strength Cond. Res. 2019, 33, 1258–1265. [Google Scholar] [CrossRef] [PubMed]
- Hopkins, W.G. A Scale of Magnitudes for Effect Statistics. Available online: http://www.sportsci.org/resource/stats/ (accessed on 30 November 2025).
- Hopkins, W.G.; Schabort, E.J.; Hawley, J.A. Reliability of power in physical performance tests. Sports Med. 2001, 31, 211–234. [Google Scholar] [CrossRef] [PubMed]
- Duncan, M.J.; Lyons, M.; Hankey, J. Placebo effects of caffeine on short-term resistance exercise to failure. Int. J. Sports Physiol. Perform. 2009, 4, 244–253. [Google Scholar] [CrossRef]



| Control | Placebo | p | Effect Size d | |
|---|---|---|---|---|
| Jump number | 13 ± 3 | 13 ± 3 | 0.187 | 0.26 |
| Mean height for the first 3 jumps (cm) | 30.6 ± 6.1 | 31.2 ± 6.1 | 0.280 | 0.28 |
| Mean height for the last 3 jumps (cm) | 27.8 ± 5.7 | 27.9 ± 5.6 | 0.867 | 0.04 |
| Control | Placebo | p | Effect Size d | |
|---|---|---|---|---|
| Bench press throw | ||||
| Propulsive mean velocity 25% (m·s−1) | 1.245 ± 0.201 | 1.268 ± 0.237 | 0.296 | 0.23 |
| Propulsive mean velocity 50% (m·s−1) | 0.785 ± 0.145 | 0.788 ± 0.142 | 0.626 | 0.10 |
| Propulsive mean velocity 75% (m·s−1) | 0.480 ± 0.131 | 0.500 ± 0.131 | 0.024 | 0.48 |
| Bench press: repetitions to failure | ||||
| Repetitions (n) | 11.0 ± 3.1 | 11.9 ± 3.7 | 0.045 | 0.42 |
| Mean first 3 repetitions (m·s−1) | 0.398 ± 0.103 | 0.413 ± 0.103 | 0.064 | 0.39 |
| Mean last 3 repetitions (m·s−1) | 0.206 ± 0.047 | 0.201 ± 0.046 | 0.469 | 0.15 |
| Mean ± SD | Affirmative Responses (%) | |
|---|---|---|
| Nervousness | 2.1 ± 1.8 | 17.4 |
| Activeness | 3.2 ± 2.3 | 34.8 |
| Irritable | 1.6 ± 1.3 | 8.7 |
| Muscular pain | 1.5 ± 1.0 | 4.3 |
| Headache | 1.4 ± 1.3 | 4.3 |
| Gastrointestinal discomfort | 1.9 ± 1.8 | 8.7 |
| Diuresis | 1.5 ± 1.2 | 4.3 |
| Sleep disorders | 1.65 ± 1.3 | 4.3 |
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Valero, F.; Viudez, C.J.; Calle, S.D.l.; González-Mohíno, F.; Salinero, J.J. Deceptive Caffeine Shows Limited Impact on Short-Term Neuromuscular Performance. Nutrients 2026, 18, 295. https://doi.org/10.3390/nu18020295
Valero F, Viudez CJ, Calle SDl, González-Mohíno F, Salinero JJ. Deceptive Caffeine Shows Limited Impact on Short-Term Neuromuscular Performance. Nutrients. 2026; 18(2):295. https://doi.org/10.3390/nu18020295
Chicago/Turabian StyleValero, Fernando, Christian José Viudez, Sergio De la Calle, Fernando González-Mohíno, and Juan José Salinero. 2026. "Deceptive Caffeine Shows Limited Impact on Short-Term Neuromuscular Performance" Nutrients 18, no. 2: 295. https://doi.org/10.3390/nu18020295
APA StyleValero, F., Viudez, C. J., Calle, S. D. l., González-Mohíno, F., & Salinero, J. J. (2026). Deceptive Caffeine Shows Limited Impact on Short-Term Neuromuscular Performance. Nutrients, 18(2), 295. https://doi.org/10.3390/nu18020295

