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Nutrients
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Dietary Supplements’ Impact on Sport Performance and Health Outcomes
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Dietary Supplements’ Impact on Sport Performance and Health Outcomes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 394

Special Issue Editors

Dr. Mon-Chien Lee

E-Mail Website
Guest Editor
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 333325, Taiwan
Interests: dietary supplementation; sports nutrition; ergogenic aids; exercise recovery; performance enhancement; metabolic regulation; nutritional interventions; personalized nutrition
Prof. Dr. Wen-Ching Huang

E-Mail Website
Guest Editor
Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
Interests: exercise training protocol; exercise physiology; muscle physiology; exercise performance; sport science; health promotion; research and development of functional health foods

Special Issue Information

Dear Colleagues,

Dietary supplementation has become essential for enhancing athletic performance and supporting overall health. Supplements such as macronutrients, vitamins, minerals, amino acids, herbal extracts, probiotics, sports drinks, and other functional ingredients have been investigated across all stages, from animal research to human studies, to evaluate their metabolic effects, impact on oxidative stress, muscle recovery, and training adaptation. Despite their widespread use, variability in formulations, dosage regimens, and individual factors, such as age, sex, training status, and genetic background, continue to challenge clear recommendations.

This Special Issue welcomes original research, systematic reviews, and meta-analyses that span the full spectrum of experimental models, refine mechanistic insights, optimize supplementation strategies, and assess performance and health outcomes. By uniting findings from basic and applied research, we aim to establish a robust translational framework for personalized and sustainable nutritional interventions in sport and exercise science.

Dr. Mon-Chien Lee
Prof. Dr. Wen-Ching Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary supplementation
  • sports nutrition
  • ergogenic aids
  • exercise recovery
  • performance enhancement
  • metabolic regulation
  • nutritional interventions
  • personalized nutrition

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Published Papers (1 paper)

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Research

18 pages, 3212 KiB  
Article
Supplementation with Live and Heat-Treated Lacticaseibacillus paracasei NB23 Enhances Endurance and Attenuates Exercise-Induced Fatigue in Mice
by Mon-Chien Lee, Ting-Yin Cheng, Ping-Jui Lin, Ting-Chun Lin, Chia-Hsuan Chou, Chao-Yuan Chen and Chi-Chang Huang
Nutrients 2025, 17(15), 2568; https://doi.org/10.3390/nu17152568 - 7 Aug 2025
Viewed by 294
Abstract
Background: Exercise-induced fatigue arises primarily from energy substrate depletion and the accumulation of metabolites such as lactate and ammonia, which impair performance and delay recovery. Emerging evidence implicates gut microbiota modulation—particularly via probiotics—as a means to optimize host energy metabolism and accelerate [...] Read more.
Background: Exercise-induced fatigue arises primarily from energy substrate depletion and the accumulation of metabolites such as lactate and ammonia, which impair performance and delay recovery. Emerging evidence implicates gut microbiota modulation—particularly via probiotics—as a means to optimize host energy metabolism and accelerate clearance of fatigue-associated by-products. Objective: This study aimed to determine whether live or heat-inactivated Lacticaseibacillus paracasei NB23 can enhance exercise endurance and attenuate fatigue biomarkers in a murine model. Methods: Forty male Institute of Cancer Research (ICR) mice were randomized into four groups (n = 10 each) receiving daily gavage for six weeks with vehicle, heat-killed NB23 (3 × 1010 cells/human/day), low-dose live NB23 (1 × 1010 CFUs/human/day), or high-dose live NB23 (3 × 1010 CFUs/human/day). Forelimb grip strength and weight-loaded swim-to-exhaustion tests assessed performance. Blood was collected post-exercise to measure serum lactate, ammonia, blood urea nitrogen (BUN), and creatine kinase (CK). Liver and muscle glycogen content was also quantified, and safety was confirmed by clinical-chemistry panels and histological examination. Results: NB23 treatment produced dose-dependent improvements in grip strength (p < 0.01) and swim endurance (p < 0.001). All NB23 groups exhibited significant reductions in post-exercise lactate (p < 0.0001), ammonia (p < 0.001), BUN (p < 0.001), and CK (p < 0.0001). Hepatic and muscle glycogen stores rose by 41–59% and 65–142%, respectively (p < 0.001). No changes in food or water intake, serum clinical-chemistry parameters, or tissue histology were observed. Conclusions: Our findings suggest that both live and heat-treated L. paracasei NB23 may contribute to improved endurance performance, increased energy reserves, and faster clearance of fatigue-related metabolites in our experimental model. However, these results should be interpreted cautiously given the exploratory nature and limitations of our study. Full article
(This article belongs to the Special Issue Dietary Supplements’ Impact on Sport Performance and Health Outcomes)
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