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Article

Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis

by 1,†, 1,†, 1, 2,* and 1,3,*
1
Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea
2
Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, Korea
3
Department of Biological Sciences, Pusan National University, Busan 46241, Korea
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Academic Editor: Karolina Szewczyk-Golec
Nutrients 2022, 14(1), 95; https://doi.org/10.3390/nu14010095
Received: 15 November 2021 / Revised: 23 December 2021 / Accepted: 24 December 2021 / Published: 27 December 2021
(This article belongs to the Special Issue Specialized Diet, Obesity and Associated Metabolic Disorders)
Increased triglyceride, cholesterol, and low-density lipoprotein (LDL) levels cause hyperlipidemia. Despite the availability of statin-based drugs to reduce LDL levels, additional effective treatments for reducing blood lipid concentrations are required. Herein, soybean hydrolysate prepared via peptic and tryptic hydrolysis promoted trans-intestinal cholesterol excretion (TICE) by increasing ATP-binding cassette subfamily G member 5 (ABCG5) and ABCG8 expression. The peptide sequence capable of promoting TICE was determined via HPLC and LC-MS/MS. Based on this, pure artificial peptides were synthesized, and the efficacy of the selected peptides was verified using cellular and hyperlipidemic mouse models. Soybean hydrolysates, including two bioactive peptides (ALEPDHRVESEGGL and SLVNNDDRDSYRLQSGDAL), promoted TICE via the expression of ABCG5 and ABCG8 in enterocytes. They downregulated expression of hepatic cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and CYP8B1 via expression of fibroblast growth factor 19 (FGF19) in a liver X receptor α (LXRa)-dependent pathway. Administration of bioactive peptides to hyperlipidemic mouse models by oral gavage reduced cholesterol levels in serum via upregulation of ABCG5 and ABCG8 expression in the proximal intestine and through fecal cholesterol excretion, upregulated FGF 15/19 expression, and suppressed hepatic bile acid synthesis. Oral administration of soybean-derived bioactive peptides elicited hypolipidemic effects by increasing TICE and decreasing hepatic cholesterol synthesis. View Full-Text
Keywords: transintestinal cholesterol excretion; soybean; hyperlipidemia; bioactive peptide transintestinal cholesterol excretion; soybean; hyperlipidemia; bioactive peptide
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MDPI and ACS Style

Lee, H.; Shin, E.; Kang, H.; Youn, H.; Youn, B. Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis. Nutrients 2022, 14, 95. https://doi.org/10.3390/nu14010095

AMA Style

Lee H, Shin E, Kang H, Youn H, Youn B. Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis. Nutrients. 2022; 14(1):95. https://doi.org/10.3390/nu14010095

Chicago/Turabian Style

Lee, Haksoo, Eunguk Shin, Hyunkoo Kang, HyeSook Youn, and BuHyun Youn. 2022. "Soybean-Derived Peptides Attenuate Hyperlipidemia by Regulating Trans-Intestinal Cholesterol Excretion and Bile Acid Synthesis" Nutrients 14, no. 1: 95. https://doi.org/10.3390/nu14010095

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