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Vitamin C in the Treatment of COVID-19

by 1,2,†, 1,2,† and 3,4,*
Pediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Center of Israel, Petach-Tikva 4920227, Israel
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Academic Editor: Anitra Carr
Nutrients 2021, 13(4), 1172;
Received: 1 March 2021 / Revised: 27 March 2021 / Accepted: 31 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Nutrition within and beyond Corona Virus)
Vitamin C is an essential nutrient that serves as antioxidant and plays a major role as co-factor and modulator of various pathways of the immune system. Its therapeutic effect during infections has been a matter of debate, with conflicting results in studies of respiratory infections and in critically ill patients. This comprehensive review aimed to summarize the current evidence regarding the use of vitamin C in the prevention or treatment of patients with SARS-CoV2 infection, based on available publications between January 2020 and February 2021. Overall, 21 publications were included in this review, consisting of case-reports and case-series, observational studies, and some clinical trials. In many of the publications, data were incomplete, and in most clinical trials the results are still pending. No studies regarding prevention of COVID-19 with vitamin C supplementation were found. Although some clinical observations reported improved medical condition of patients with COVID-19 treated with vitamin C, available data from controlled studies are scarce and inconclusive. Based on the theoretical background presented in this article, and some preliminary encouraging studies, the role of vitamin C in the treatment of patients with SARS-CoV-2 infection should be further investigated. View Full-Text
Keywords: ascorbic acid; SARS-CoV-2; antioxidant; immune regulation ascorbic acid; SARS-CoV-2; antioxidant; immune regulation
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MDPI and ACS Style

Milani, G.P.; Macchi, M.; Guz-Mark, A. Vitamin C in the Treatment of COVID-19. Nutrients 2021, 13, 1172.

AMA Style

Milani GP, Macchi M, Guz-Mark A. Vitamin C in the Treatment of COVID-19. Nutrients. 2021; 13(4):1172.

Chicago/Turabian Style

Milani, Gregorio P., Marina Macchi, and Anat Guz-Mark. 2021. "Vitamin C in the Treatment of COVID-19" Nutrients 13, no. 4: 1172.

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