Next Article in Journal
Vitamin C in the Treatment of COVID-19
Next Article in Special Issue
Histamine Intolerance in Children: A Narrative Review
Previous Article in Journal
Assessing the Impact of Salt Reduction Initiatives on the Chronic Disease Burden of Singapore
Previous Article in Special Issue
Assessment of Inflammatory Markers in Children with Cow’s Milk Allergy Treated with a Milk-Free Diet
Article

The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study

1
Department of Pathomorphology, the Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland
2
Outpatient Allergology and Dermatology Clinic, Patriotów St. 100, 04-844 Warsaw, Poland
3
Department of Developmental Age Medicine and Paediatric Nursing, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna St. 37, 15-295 Białystok, Poland
4
Outpatient Allergology Clinic, the Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland
5
Outpatient Dermatology Clinic, Chodakowska St. 8, 96-503 Sochaczew, Poland
6
Department of Environmental Biotechnology, Lodz University of Technology, Wólczańska 171/173, 90-924 Łódź, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Grazyna Czaja-Bulsa
Nutrients 2021, 13(4), 1169; https://doi.org/10.3390/nu13041169
Received: 2 March 2021 / Revised: 25 March 2021 / Accepted: 29 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Food Sensitivity: Causes and Management)
Probiotics seem to have promising effects in the prevention and treatment of allergic conditions including atopic dermatitis (AD) and food allergy. The purpose of this multicenter randomized placebo-controlled trial was to evaluate the effectiveness of a probiotic preparation comprising Lactobacillus rhamnosus ŁOCK 0900, Lactobacillus rhamnosus ŁOCK 0908, and Lactobacillus casei ŁOCK 0918 in children under 2 years of age with AD and a cow’s milk protein (CMP) allergy. The study enrolled 151 children, who—apart from being treated with a CMP elimination diet—were randomized to receive the probiotic preparation at a daily dose of 109 bacteria or a placebo for three months, with a subsequent nine-month follow-up. The primary outcomes included changes in AD symptom severity assessed with the scoring AD (SCORAD) index and in the proportion of children with symptom improvement (a SCORAD score decreased by at least 30% in comparison with that at baseline). After the three-month intervention, both the probiotic and placebo groups showed a significant (p < 0.0001) decrease in SCORAD scores, which was maintained nine months later. The percentage of children who showed improvement was significantly higher in the probiotic than in the placebo group (odds ratio (OR) 2.56; 95% confidence interval (CI) 1.13–5.8; p = 0.012) after three months. Probiotics induced SCORAD improvement mainly in allergen sensitized patients (OR 6.03; 95% CI 1.85–19.67, p = 0.001), but this positive effect was not observed after nine months. The results showed that the mixture of probiotic ŁOCK strains offers benefits for children with AD and CMP allergy. Further research is necessary to assess the effect of probiotic supplementation on the development of immune tolerance (NCT04738565). View Full-Text
Keywords: probiotics; atopic dermatitis; food allergy; cow’s milk protein allergy; Lactobacillus rhamnosus; Lactobacillus casei probiotics; atopic dermatitis; food allergy; cow’s milk protein allergy; Lactobacillus rhamnosus; Lactobacillus casei
Show Figures

Graphical abstract

MDPI and ACS Style

Cukrowska, B.; Ceregra, A.; Maciorkowska, E.; Surowska, B.; Zegadło-Mylik, M.A.; Konopka, E.; Trojanowska, I.; Zakrzewska, M.; Bierła, J.B.; Zakrzewski, M.; Kanarek, E.; Motyl, I. The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients 2021, 13, 1169. https://doi.org/10.3390/nu13041169

AMA Style

Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło-Mylik MA, Konopka E, Trojanowska I, Zakrzewska M, Bierła JB, Zakrzewski M, Kanarek E, Motyl I. The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021; 13(4):1169. https://doi.org/10.3390/nu13041169

Chicago/Turabian Style

Cukrowska, Bożena, Aldona Ceregra, Elżbieta Maciorkowska, Barbara Surowska, Maria A. Zegadło-Mylik, Ewa Konopka, Ilona Trojanowska, Magdalena Zakrzewska, Joanna B. Bierła, Mateusz Zakrzewski, Ewelina Kanarek, and Ilona Motyl. 2021. "The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study" Nutrients 13, no. 4: 1169. https://doi.org/10.3390/nu13041169

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop