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Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length—The Special Turku Coronary Risk Factor Intervention Project (STRIP)

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Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland
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Centre for Population Health Research, University of Turku and Turku University Hospital, 20520 Turku, Finland
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Auria Biobank, University of Turku and Turku University Hospital, 20520 Turku, Finland
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Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, 20520 Turku, Finland
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Minerva Institute for Medical Research, 00290 Helsinki, Finland
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Department of Public Health Solutions, Institute for Health and Welfare, 20750 Turku, Finland
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Department of Public Health, University of Turku and Turku University Hospital, 20520 Turku, Finland
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Department of Medicine, University of Turku, 20520 Turku, Finland
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Division of Medicine, Turku University Hospital, 20520 Turku, Finland
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Department of Physiology and Department of Pediatrics, University of Turku, 20520 Turku, Finland
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Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, 20520 Turku, Finland
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Amelia Martí
Nutrients 2021, 13(2), 318; https://doi.org/10.3390/nu13020318
Received: 23 December 2020 / Revised: 13 January 2021 / Accepted: 19 January 2021 / Published: 22 January 2021
(This article belongs to the Section Nutritional Epidemiology)
Reduced telomere length (TL) is a biological marker of aging. A high inter-individual variation in TL exists already in childhood, which is partly explained by genetics, but also by lifestyle factors. We examined the influence of a 20-year dietary/lifestyle intervention on TL attrition from childhood to early adulthood. The study comprised participants of the longitudinal randomized Special Turku Coronary Risk Factor Intervention Project (STRIP) conducted between 1990 and 2011. Healthy 7-month-old children were randomized to the intervention group (n = 540) receiving dietary counseling mainly focused on dietary fat quality and to the control group (n = 522). Leukocyte TL was measured using the Southern blot method from whole blood samples collected twice: at a mean age of 7.5 and 19.8 years (n = 232; intervention n = 108, control n = 124). Yearly TL attrition rate was calculated. The participants of the intervention group had slower yearly TL attrition rate compared to the controls (intervention: mean = −7.5 bp/year, SD = 24.4 vs. control: mean = −15.0 bp/year, SD = 30.3; age, sex and baseline TL adjusted β = 0.007, SE = 0.004, p = 0.040). The result became stronger after additional adjustments for dietary fat quality and fiber intake, serum lipid and insulin concentrations, systolic blood pressure, physical activity and smoking (β = 0.013, SE = 0.005, p = 0.009). A long-term intervention focused mainly on dietary fat quality may affect the yearly TL attrition rate in healthy children/adolescents. View Full-Text
Keywords: telomere length; telomere attrition; dietary intervention; childhood; genetics; risk factors telomere length; telomere attrition; dietary intervention; childhood; genetics; risk factors
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MDPI and ACS Style

Pitkänen, N.; Pahkala, K.; Rovio, S.P.; Saijonmaa, O.J.; Nyman, A.E.; Jula, A.; Lagström, H.; Viikari, J.S.A.; Rönnemaa, T.; Niinikoski, H.; Simell, O.; Fyhrquist, F.; Raitakari, O.T. Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length—The Special Turku Coronary Risk Factor Intervention Project (STRIP). Nutrients 2021, 13, 318. https://doi.org/10.3390/nu13020318

AMA Style

Pitkänen N, Pahkala K, Rovio SP, Saijonmaa OJ, Nyman AE, Jula A, Lagström H, Viikari JSA, Rönnemaa T, Niinikoski H, Simell O, Fyhrquist F, Raitakari OT. Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length—The Special Turku Coronary Risk Factor Intervention Project (STRIP). Nutrients. 2021; 13(2):318. https://doi.org/10.3390/nu13020318

Chicago/Turabian Style

Pitkänen, Niina, Katja Pahkala, Suvi P. Rovio, Outi J. Saijonmaa, Anna E. Nyman, Antti Jula, Hanna Lagström, Jorma S.A. Viikari, Tapani Rönnemaa, Harri Niinikoski, Olli Simell, Frej Fyhrquist, and Olli T. Raitakari. 2021. "Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length—The Special Turku Coronary Risk Factor Intervention Project (STRIP)" Nutrients 13, no. 2: 318. https://doi.org/10.3390/nu13020318

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