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Article

Effects of Maternal Fiber Intake on Intestinal Morphology, Bacterial Profile and Proteome of Newborns Using Pig as Model

1
Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China
2
College of Food Science, Sichuan Agricultural University, Ya’an 625014, China
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 42; https://doi.org/10.3390/nu13010042
Received: 13 November 2020 / Revised: 14 December 2020 / Accepted: 21 December 2020 / Published: 25 December 2020
(This article belongs to the Section Phytochemicals and Human Health)
Dietary fiber intake during pregnancy may improve offspring intestinal development. The aim of this study was to evaluate the effect of maternal high fiber intake during late gestation on intestinal morphology, microbiota, and intestinal proteome of newborn piglets. Sixteen sows were randomly allocated into two groups receiving the control diet (CD) and high-fiber diet (HFD) from day 90 of gestation to farrowing. Newborn piglets were selected from each litter, named as CON and Fiber group, respectively. Maternal high fiber intake did not markedly improve the birth weight, but increased the body length, the ileal crypt depth and colonic acetate level. In addition, maternal high fiber intake increased the -diversity indices (Observed species, Simpson, and ACE), and the abundance of Acidobacteria and Bacteroidetes at phylum level, significantly increased the abundance of Bradyrhizobium and Phyllobacterium at genus level in the colon of newborn piglets. Moreover, maternal high fiber intake markedly altered the ileal proteome, increasing the abundances of proteins associated with oxidative status, energy metabolism, and immune and inflammatory responses, and decreasing abundances of proteins related to cellular apoptosis, cell structure, and motility. These findings indicated that maternal high fiber intake could alter intestinal morphology, along with the altered intestinal microbiota composition and proteome of offspring. View Full-Text
Keywords: maternal fiber intake; intestinal morphology; bacterial profile; proteome; newborn piglets maternal fiber intake; intestinal morphology; bacterial profile; proteome; newborn piglets
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MDPI and ACS Style

He, Y.; Peng, X.; Liu, Y.; Wu, Q.; Zhou, Q.; Hu, L.; Fang, Z.; Lin, Y.; Xu, S.; Feng, B.; Li, J.; Zhuo, Y.; Wu, D.; Che, L. Effects of Maternal Fiber Intake on Intestinal Morphology, Bacterial Profile and Proteome of Newborns Using Pig as Model. Nutrients 2021, 13, 42. https://doi.org/10.3390/nu13010042

AMA Style

He Y, Peng X, Liu Y, Wu Q, Zhou Q, Hu L, Fang Z, Lin Y, Xu S, Feng B, Li J, Zhuo Y, Wu D, Che L. Effects of Maternal Fiber Intake on Intestinal Morphology, Bacterial Profile and Proteome of Newborns Using Pig as Model. Nutrients. 2021; 13(1):42. https://doi.org/10.3390/nu13010042

Chicago/Turabian Style

He, Ying, Xie Peng, Yang Liu, Qing Wu, Qiang Zhou, Liang Hu, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Jian Li, Yong Zhuo, De Wu, and Lianqiang Che. 2021. "Effects of Maternal Fiber Intake on Intestinal Morphology, Bacterial Profile and Proteome of Newborns Using Pig as Model" Nutrients 13, no. 1: 42. https://doi.org/10.3390/nu13010042

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