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Open AccessArticle

The Oak–wood Extract Robuvit® Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Pilot Study

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Department of II. Gynecology and Obstetrics, Medical Faculty, Comenius University, 82606 Bratislava, Slovakia
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Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty, Comenius University, 81108 Bratislava, Slovakia
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Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 81108 Bratislava, Slovakia
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Center of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, 84104 Bratislava, Slovakia
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Faculty of Natural Sciences, Comenius University in Bratislava, 84215 Bratislava, Slovakia
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Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg, 97074 Würzburg, Germany
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Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 913; https://doi.org/10.3390/nu12040913 (registering DOI)
Received: 10 March 2020 / Revised: 23 March 2020 / Accepted: 25 March 2020 / Published: 27 March 2020
(This article belongs to the Section Clinical Nutrition)
Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40% polyphenols of the ellagitannins class, Robuvit®, on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit® (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP–9 activity was significantly reduced by Robuvit® versus placebo. After 8 weeks of intervention, the patients’ condition improved independently of the intervention. Our results suggest that the use of Robuvit® as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).
Keywords: hysterectomy; Robuvit®; oak wood extract; post-operative recovery; oxidative stress; matrix metalloproteinases; complementary medicine hysterectomy; Robuvit®; oak wood extract; post-operative recovery; oxidative stress; matrix metalloproteinases; complementary medicine
MDPI and ACS Style

Ferianec, V.; Fülöp, M.; Ježovičová, M.; Radošinská, J.; Husseinová, M.; Feriancová, M.; Radošinská, D.; Barančík, M.; Muchová, J.; Hȍgger, P.; Ďuračková, Z. The Oak–wood Extract Robuvit® Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Pilot Study. Nutrients 2020, 12, 913.

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