Next Article in Journal
Malnutrition at Admission Predicts In-Hospital Falls in Hospitalized Older Adults
Previous Article in Journal
Chrono-Nutrition and Diet Quality in Adolescents with Delayed Sleep-Wake Phase Disorder
Open AccessArticle

A Whole-Food-Based Health Product (A-F Betafood®) Improves Gallbladder Function in Humans at Risk of Gallbladder Insufficiency: A Randomized, Placebo-Controlled Clinical Trial

1
KGK Science, London, ON N6A 5R8, Canada
2
Standard Process Inc, Palmyra, WI 53156, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 540; https://doi.org/10.3390/nu12020540
Received: 10 January 2020 / Revised: 7 February 2020 / Accepted: 13 February 2020 / Published: 20 February 2020
(This article belongs to the Section Clinical Nutrition)
A-F Betafood® is a whole food-based health product. The product contains phytonutrients and bioactives with antioxidant properties that may support gallbladder and liver function. Herein, we investigated the efficacy of A-F Betafood® on gallbladder and liver function. In this randomized, placebo-controlled, parallel study fifty overweight but otherwise healthy adults received A-F Betafood® or placebo for 12 weeks. Gallbladder function as assessed by gallbladder volume, ejection fraction (GBEF), ejection rate, wall thickness and liver function determined via aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase, and high-sensitivity c-reactive protein analysis at baseline and week 12 were the primary outcomes. Total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglycerides, and oxidative stress markers including oxidized low-density lipoprotein, tumor necrosis factor-α, adiponectin and malonyldialdehyde (MDA) were assessed as secondary outcomes. A-F Betafood®-supplementation significantly reduced gallbladder wall thickness (p = 0.049) by 9% compared to placebo from baseline to week 12. The A-F Betafood® group alone had significant improvements in gallbladder volume (32%; p = 0.044) and GBEF (19%; p = 0.047) at week 12. There were no changes in liver function, oxidative stress markers or blood lipid concentrations, though MDA concentrations decreased in both groups. Our findings demonstrate A-F Betafood®-supplementation significantly improves measures of gallbladder function and support healthy gallbladder function in the individuals with gall bladder condition. View Full-Text
Keywords: A-F Betafood®; beets; randomized; double-blind; placebo-controlled; gallbladder condition; gallbladder function; liver function A-F Betafood®; beets; randomized; double-blind; placebo-controlled; gallbladder condition; gallbladder function; liver function
Show Figures

Figure 1

MDPI and ACS Style

Evans, M.; Guthrie, N.; El-Khodor, B.F.; Metzger, B.; Varadharaj, S. A Whole-Food-Based Health Product (A-F Betafood®) Improves Gallbladder Function in Humans at Risk of Gallbladder Insufficiency: A Randomized, Placebo-Controlled Clinical Trial. Nutrients 2020, 12, 540. https://doi.org/10.3390/nu12020540

AMA Style

Evans M, Guthrie N, El-Khodor BF, Metzger B, Varadharaj S. A Whole-Food-Based Health Product (A-F Betafood®) Improves Gallbladder Function in Humans at Risk of Gallbladder Insufficiency: A Randomized, Placebo-Controlled Clinical Trial. Nutrients. 2020; 12(2):540. https://doi.org/10.3390/nu12020540

Chicago/Turabian Style

Evans, Malkanthi; Guthrie, Najla; El-Khodor, Bassem F.; Metzger, Brandon; Varadharaj, Saradhadevi. 2020. "A Whole-Food-Based Health Product (A-F Betafood®) Improves Gallbladder Function in Humans at Risk of Gallbladder Insufficiency: A Randomized, Placebo-Controlled Clinical Trial" Nutrients 12, no. 2: 540. https://doi.org/10.3390/nu12020540

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop