Next Article in Journal
Postural Balance Effects Associated with 400, 4000 or 10,000 IU Vitamin D3 Daily for Three Years: A Secondary Analysis of a Randomized Clinical Trial
Previous Article in Journal
Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 12
Issue 2
10.3390/nu12020526
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study

by
Shuai Yuan
1,2,
Paul Carter
3,
Mathew Vithayathil
4,
Siddhartha Kar
3,5,
Edward Giovannucci
6,7,
Amy M. Mason
3,
Stephen Burgess
3,8 and
Susanna C. Larsson
1,2,*
1
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden
2
Department of Surgical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden
3
Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
4
MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK
5
MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 1QU, UK
6
Departments of Epidemiology and Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
7
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, USA
8
MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 526; https://doi.org/10.3390/nu12020526
Submission received: 22 January 2020 / Revised: 17 February 2020 / Accepted: 18 February 2020 / Published: 19 February 2020
Versions Notes

Abstract

We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a genome-wide association study of 48,972 European-descent individuals. Summary-level data for breast and other cancers were obtained from the Breast Cancer Association Consortium and UK Biobank. Genetically predicted iron status was positively associated with liver cancer and inversely associated with brain cancer but not associated with overall cancer or the other 20 studied cancer sites at p < 0.05. The odds ratios of liver cancer were 2.45 (95% CI, 0.81, 7.45; p = 0.11), 2.11 (1.16, 3.83; p = 0.02), 10.89 (2.44, 48.59; p = 0.002) and 0.30 (0.17, 0.53; p = 2 × 10−5) for one standard deviation increment of serum iron, transferrin saturation, ferritin and transferrin levels, respectively. For brain cancer, the corresponding odds ratios were 0.69 (0.48, 1.00; p = 0.05), 0.75 (0.59, 0.97; p = 0.03), 0.41 (0.20, 0.88; p = 0.02) and 1.49 (1.04, 2.14; p = 0.03). Genetically high iron status was positively associated with liver cancer and inversely associated with brain cancer.
Keywords: iron; transferrin saturation; ferritin; serum transferrin; cancer; Mendelian randomization iron; transferrin saturation; ferritin; serum transferrin; cancer; Mendelian randomization

Share and Cite

MDPI and ACS Style

Yuan, S.; Carter, P.; Vithayathil, M.; Kar, S.; Giovannucci, E.; Mason, A.M.; Burgess, S.; Larsson, S.C. Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study. Nutrients 2020, 12, 526. https://doi.org/10.3390/nu12020526

AMA Style

Yuan S, Carter P, Vithayathil M, Kar S, Giovannucci E, Mason AM, Burgess S, Larsson SC. Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study. Nutrients. 2020; 12(2):526. https://doi.org/10.3390/nu12020526

Chicago/Turabian Style

Yuan, Shuai, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Edward Giovannucci, Amy M. Mason, Stephen Burgess, and Susanna C. Larsson. 2020. "Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study" Nutrients 12, no. 2: 526. https://doi.org/10.3390/nu12020526

APA Style

Yuan, S., Carter, P., Vithayathil, M., Kar, S., Giovannucci, E., Mason, A. M., Burgess, S., & Larsson, S. C. (2020). Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study. Nutrients, 12(2), 526. https://doi.org/10.3390/nu12020526

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop