Gut Feelings: How Microbiota Might Impact the Development and Course of Anorexia Nervosa
Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, RWTH University Hospital, Neuenhofer Weg 21, 52074 Aachen, Germany
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Nutrients 2020, 12(11), 3295; https://doi.org/10.3390/nu12113295
Received: 4 September 2020
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Revised: 20 October 2020
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Accepted: 22 October 2020
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Published: 28 October 2020
(This article belongs to the Special Issue Diet, Gut Microbiota and Metabolic Disorders)
Anorexia nervosa (AN) can probably be regarded as a “model” for studying the interaction of nutrition with the gut–brain axis, which has drawn increased attention from researchers and clinicians alike. The gut microbiota influences somatic effects, such as energy extraction from food and body weight gain, as well as appetite, gut permeability, inflammation and complex psychological behaviors, such as depression or anxiety, all of which play important roles in AN. As nutrition is one of the main factors that influence the gut microbiota, nutritional restriction and selective eating in AN are likely influencing factors; however, nutritional rehabilitation therapy is surprisingly understudied. Here, we review the general mechanisms of the interactions between nutrition, the gut microbiota and the host that may be relevant to AN, paying special attention to the gut–brain axis, and we present the first specific findings in patients with AN and corresponding animal models. In particular, nutritional interventions, including food selection, supplements, and pre-, pro- and synbiotics that have the potential to influence the gut microbiota, are important research targets to potentially support future AN therapy.
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Keywords:
anorexia nervosa; gut microbiota; diet; nutrition; gut brain interaction; Lachnospiraceae; prediction; autoimmune; inflammation; gut permeability
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MDPI and ACS Style
Seitz, J.; Dahmen, B.; Keller, L.; Herpertz-Dahlmann, B. Gut Feelings: How Microbiota Might Impact the Development and Course of Anorexia Nervosa. Nutrients 2020, 12, 3295. https://doi.org/10.3390/nu12113295
AMA Style
Seitz J, Dahmen B, Keller L, Herpertz-Dahlmann B. Gut Feelings: How Microbiota Might Impact the Development and Course of Anorexia Nervosa. Nutrients. 2020; 12(11):3295. https://doi.org/10.3390/nu12113295
Chicago/Turabian StyleSeitz, Jochen, Brigitte Dahmen, Lara Keller, and Beate Herpertz-Dahlmann. 2020. "Gut Feelings: How Microbiota Might Impact the Development and Course of Anorexia Nervosa" Nutrients 12, no. 11: 3295. https://doi.org/10.3390/nu12113295
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