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Open AccessArticle

Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial

1
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea
2
LG Household and Healthcare Research Park, Seoul 07795, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3237; https://doi.org/10.3390/nu12113237
Received: 21 September 2020 / Revised: 16 October 2020 / Accepted: 20 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue Nutrition Challenges for Middle-Aged and Older Women)
This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women. View Full-Text
Keywords: Pueraria thomsonii; Citrus unshiu; menopause; hot flash; bone resorption Pueraria thomsonii; Citrus unshiu; menopause; hot flash; bone resorption
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MDPI and ACS Style

Kim, J.E.; Jeong, H.; Hur, S.; Lee, J.; Kwon, O. Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial. Nutrients 2020, 12, 3237.

AMA Style

Kim JE, Jeong H, Hur S, Lee J, Kwon O. Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial. Nutrients. 2020; 12(11):3237.

Chicago/Turabian Style

Kim, Ji E.; Jeong, Hyeyun; Hur, Soohee; Lee, Junho; Kwon, Oran. 2020. "Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial" Nutrients 12, no. 11: 3237.

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