Next Article in Journal
Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses
Previous Article in Journal
The Role of a Nutrition Support Team in the Management of Intestinal Failure Patients
Open AccessArticle

Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract

1
College of Pharmacy, Pusan National University, Busan 46241, Korea
2
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Korea
3
International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
4
Ethnobotanical Database of Bangladesh, Dhaka 1208, Bangladesh
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(1), 173; https://doi.org/10.3390/nu12010173
Received: 5 October 2019 / Revised: 30 December 2019 / Accepted: 3 January 2020 / Published: 8 January 2020
Wikstroemia indica (L.) C.A. Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the effects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at a W. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD. View Full-Text
Keywords: Wikstroemia indica; 2,4-dinitrochlorobenzene; atopic dermatitis; transepidermal water loss; interleukin Wikstroemia indica; 2,4-dinitrochlorobenzene; atopic dermatitis; transepidermal water loss; interleukin
Show Figures

Figure 1

MDPI and ACS Style

Lee, S.-Y.; Park, N.-J.; Jegal, J.; Jo, B.-G.; Choi, S.; Lee, S.W.; Uddin, M.S.; Kim, S.-N.; Yang, M.H. Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract. Nutrients 2020, 12, 173.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop