Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review
by
Sanne Verhoog 1,*
, Petek Eylul Taneri 2, Zayne M. Roa Díaz 1, Pedro Marques-Vidal 3, John P. Troup 4, Lia Bally 5, Oscar H. Franco 1, Marija Glisic 6 and Taulant Muka 1
Sanne Verhoog 1,*, Petek Eylul Taneri 2, Zayne M. Roa Díaz 1, Pedro Marques-Vidal 3, John P. Troup 4, Lia Bally 5, Oscar H. Franco 1, Marija Glisic 6 and Taulant Muka 1
1
Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland
2
Corlu Cancer Early Diognosis and Training Center, 59100 Tekirdag, Turkey
3
Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland
4
Standard Process Inc Nutrition Innovation Center, Kannapolis, NC 28018, USA
5
Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Bern University Hospital, 3010 Bern, Switzerland
6
Leibniz Institute for Prevention Research and Epidemiology-BIPS, 28359 Bremen, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1565; https://doi.org/10.3390/nu11071565
Received: 6 June 2019 / Revised: 5 July 2019 / Accepted: 8 July 2019 / Published: 11 July 2019
(This article belongs to the Special Issue Dietary Bioactives and Human Health)
Akkermansia muciniphila and Faecalibacterium prausnitzii are highly abundant human gut microbes in healthy individuals, and reduced levels are associated with inflammation and alterations of metabolic processes involved in the development of type 2 diabetes. Dietary factors can influence the abundance of A. muciniphila and F. prausnitzii, but the evidence is not clear. We systematically searched PubMed and Embase to identify clinical trials investigating any dietary intervention in relation to A. muciniphila and F. prausnitzii. Overall, 29 unique trials were included, of which five examined A. muciniphila, 19 examined F. prausnitzii, and six examined both, in a total of 1444 participants. A caloric restriction diet and supplementation with pomegranate extract, resveratrol, polydextrose, yeast fermentate, sodium butyrate, and inulin increased the abundance of A. muciniphila, while a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols decreased the abundance of A. muciniphila. For F. prausnitzii, the main studied intervention was prebiotics (e.g. fructo-oligosaccharides, inulin type fructans, raffinose); seven studies reported an increase after prebiotic intervention, while two studies reported a decrease, and four studies reported no difference. Current evidence suggests that some dietary factors may influence the abundance of A. muciniphila and F. prausnitzii. However, more research is needed to support these microflora strains as targets of microbiome shifts with dietary intervention and their use as medical nutrition therapy in prevention and management of chronic disease.
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Keywords:
Akkermansia muciniphila; Faecalibacterium prausnitzii; microbiome; systematic review; randomized controlled trials; dietary interventions
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MDPI and ACS Style
Verhoog, S.; Taneri, P.E.; Roa Díaz, Z.M.; Marques-Vidal, P.; Troup, J.P.; Bally, L.; Franco, O.H.; Glisic, M.; Muka, T. Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review. Nutrients 2019, 11, 1565.
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