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The Impact of a Diet Containing Sucrose and Systematically Repeated Starvation on the Oxidative Status of the Uterus and Ovary of Rats

1
Department of Human Nutrition Physiology, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology, ul. Papieża Pawła VI 3, 71-459 Szczecin, Poland
2
Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, ul. Żołnierska 54, 71-210 Szczecin, Poland
3
Department of Physiology, Faculty of Biology, University of Szczecin, ul. Felczaka 3c, 71-412 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1544; https://doi.org/10.3390/nu11071544
Received: 3 June 2019 / Revised: 1 July 2019 / Accepted: 2 July 2019 / Published: 8 July 2019
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Abstract

The effect of a sucrose diet and repeated one-day starvation on oxidative status in the ovary and uterus is still unknown. Our analysis focused on carbohydrate-lipid metabolism parameters and the changes in red blood cells, ovary and uterus superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and malonylodialdehyde (MDA) concentration in rats fed with a diet containing 16% of sucrose and subjected to systematic one-day starvation when using such a diet. It was found that a diet with 16% sucrose contributed to the increase of antioxidant enzyme activity in the blood (GPx and CAT) and uterus (SOD), without changes in MDA concentrations, which indicates an increase in reactive oxygen species (ROS) concentration in these tissues, being balanced by an increase in antioxidant enzyme activity. The introduction of a regular one-day starvation period into the diet intensified oxidative stress and led to a redox imbalance in the reproductive tissues of female rats. This was manifested by higher GPx activity, lower CAT activity and higher MDA concentration in the uterus and lower GPx and CAT activities and lower MDA concentration in the ovaries. The observed changes may be the cause of fertility disorders and possible problems with fertilised egg cell implantation into the uterine tissue. View Full-Text
Keywords: sucrose; starvation; carbohydrate-lipid metabolism; oxidative status; uterus; ovary; rat sucrose; starvation; carbohydrate-lipid metabolism; oxidative status; uterus; ovary; rat
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Sadowska, J.; Dudzińska, W.; Skotnicka, E.; Sielatycka, K.; Daniel, I. The Impact of a Diet Containing Sucrose and Systematically Repeated Starvation on the Oxidative Status of the Uterus and Ovary of Rats. Nutrients 2019, 11, 1544.

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