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Nutrients
Volume 11
Issue 2
10.3390/nu11020313
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Article

Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice

by
Umesh D. Wankhade
1,2,*,
Ying Zhong
2,
Oxana P. Lazarenko
2,
Sree V. Chintapalli
1,2,
Brian D. Piccolo
1,2,
Jin-Ran Chen
1,2 and
Kartik Shankar
1,2
1
Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 722025, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 313; https://doi.org/10.3390/nu11020313
Submission received: 11 December 2018 / Revised: 25 January 2019 / Accepted: 27 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue Dietary Anthocyanins and Human Health)
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Abstract

The antioxidant and anti-inflammatory properties of blueberries improve vascular function and insulin sensitivity. However, the bioavailability of the active compounds in blueberries is largely dependent on the gut microbiota, which may themselves be altered by blueberry components. The objective of the current study was to explore a possible sex-dependent modulation of the gut microbiota following supplementation with blueberries in adult mice. Eight-week-old C57BL/6J mice (n = 7–10/group) were provided with control or blueberry-containing diets (5% freeze-dried powder) for 4 weeks. Body weight, composition, and food intake were measured weekly. Genomic DNA was isolated from the cecal contents for 16S rRNA sequencing. Blueberry feeding decreased α-diversity (operational taxonomical unit abundance) and altered β-diversity (p < 0.05). At the phylum level, the Firmicutes to Bacteroidetes ratio was significantly lower in the blueberry-fed groups (p < 0.001), along with increased Tenericutes and decreased Deferribacteres. At the genus level, blueberry feeding led to sexually-dimorphic differences, which were associated with predicted metabolic pathways. Pathways such as fatty acid and lipid metabolism were significantly different and demonstrated a stronger association with microbes in the male. To summarize, blueberry supplementation led to sexually-dimorphic global changes in the gut microbiome, which could possibly contribute to physiological changes in mice.
Keywords: microbiome; anthocyanins; blueberry; sexual dimorphism microbiome; anthocyanins; blueberry; sexual dimorphism

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MDPI and ACS Style

Wankhade, U.D.; Zhong, Y.; Lazarenko, O.P.; Chintapalli, S.V.; Piccolo, B.D.; Chen, J.-R.; Shankar, K. Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice. Nutrients 2019, 11, 313. https://doi.org/10.3390/nu11020313

AMA Style

Wankhade UD, Zhong Y, Lazarenko OP, Chintapalli SV, Piccolo BD, Chen J-R, Shankar K. Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice. Nutrients. 2019; 11(2):313. https://doi.org/10.3390/nu11020313

Chicago/Turabian Style

Wankhade, Umesh D., Ying Zhong, Oxana P. Lazarenko, Sree V. Chintapalli, Brian D. Piccolo, Jin-Ran Chen, and Kartik Shankar. 2019. "Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice" Nutrients 11, no. 2: 313. https://doi.org/10.3390/nu11020313

APA Style

Wankhade, U. D., Zhong, Y., Lazarenko, O. P., Chintapalli, S. V., Piccolo, B. D., Chen, J.-R., & Shankar, K. (2019). Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice. Nutrients, 11(2), 313. https://doi.org/10.3390/nu11020313

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