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The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns

1
Division of Gynecological Surgery, Poznań University of Medical Sciences, 60-535 Poznań, Poland
2
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 71-252 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2298; https://doi.org/10.3390/nu11102298
Received: 22 August 2019 / Revised: 19 September 2019 / Accepted: 24 September 2019 / Published: 26 September 2019
It has not yet been established, whether or not the maternal serum selenium (Se) in early pregnancy may be a risk marker of small-for-gestational age (SGA) birth weight. Selenium is important for human health and is involved in oxidative balance, a key element in the development of the placenta and fetus. This innovative study was nested in a prospective cohort of 750 women recruited in the 10–14th week of a single pregnancy, all of whom were healthy during recruitment. We examined mothers delivering SGA infants (with birth weight <10th percentile) (n = 48) and matched mothers delivering appropriate-for-gestational age (AGA) infants (between 10–90th percentile) (n = 192). We measured the maternal microelement concentrations in the serum from the 10–14th gestational week, using the inductively coupled plasma mass spectrometry (ICP-MS). The odds ratios of SGA (and 95% confidence intervals) were assessed in logistic regression. The mean maternal Se concentrations were lower in mothers in the SGA group compared to the AGA group (59.60 vs. 62.54 µg/L; p = 0.020). Women in the lowest Q1 quartile of Se (≤56.60 µg/L) have about three times higher risk of SGA compared to women in the higher quartiles (Q2 or Q4); the odds ratio of SGA was OR = 3.02 (p = 0.019) for Q1 vs. Q2 quartile. The risk profile graph confirms the results. We found that excessive pre-pregnancy BMI (body mass index) affected the estimated SGA odds ratios. Early pregnancy maternal serum selenium status can be a risk marker of SGA newborns and more research is needed in larger groups. View Full-Text
Keywords: selenium; fetus; weight; newborn; SGA; pregnancy; AGA; microelement; trace element selenium; fetus; weight; newborn; SGA; pregnancy; AGA; microelement; trace element
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MDPI and ACS Style

Lewandowska, M.; Sajdak, S.; Lubiński, J. The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns. Nutrients 2019, 11, 2298. https://doi.org/10.3390/nu11102298

AMA Style

Lewandowska M, Sajdak S, Lubiński J. The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns. Nutrients. 2019; 11(10):2298. https://doi.org/10.3390/nu11102298

Chicago/Turabian Style

Lewandowska, Małgorzata, Stefan Sajdak, and Jan Lubiński. 2019. "The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns" Nutrients 11, no. 10: 2298. https://doi.org/10.3390/nu11102298

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