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Nutrients 2019, 11(1), 148;

Dietary Inflammatory Index Score and Its Association with Body Weight, Blood Pressure, Lipid Profile, and Leptin in Indonesian Adults

Department of Nutrition and Health, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
NUTRIM School of Translational Nutrition and Metabolism, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
International Institute for Global Health, United Nations University, Kuala Lumpur 16150, Malaysia
Center for Southeast Asian Studies, Kyoto University, Kyoto 606-8501, Japan
Author to whom correspondence should be addressed.
Received: 23 November 2018 / Revised: 24 December 2018 / Accepted: 25 December 2018 / Published: 11 January 2019
(This article belongs to the Special Issue Inflammation- An Ancient Battle. What are the Roles of Nutrients?)
PDF [267 KB, uploaded 11 January 2019]


It was previously reported that dietary intake is an important trigger for systemic inflammation and one of the lifestyle factors for the development of cardiovascular diseases. The aim of this study was to evaluate the association between Dietary Inflammatory Index (DII) score and body weight, blood pressure, lipid profile and leptin in an Indonesian population. This was a cross-sectional study conducted in 503 Indonesian adults. The DII score was calculated based on data of 30 nutrients and food components. Anthropometric profile, blood pressure, lipid profile, and leptin were measured. The association of these variables with the DII score was analyzed. The DII score was not associated with body weight, body mass index (BMI), body fat, waist circumference, hip circumference, systolic and diastolic blood pressure, triglycerides, and high-density lipoprotein (HDL) (both unadjusted and after adjustment for covariates). However, plasma leptin concentration was significantly associated with the DII score (B = 0.096, p = 0.020). Plasma leptin also increased significantly across tertiles of the DII score (ANCOVA, p = 0.031). This positive association between the DII score and plasma leptin concentration suggests a role for the inflammatory properties of the diet in regulating adipose tissue inflammation. View Full-Text
Keywords: dietary inflammatory index; obesity; triglyceride; HDL; leptin dietary inflammatory index; obesity; triglyceride; HDL; leptin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Muhammad, H.F.L.; van Baak, M.A.; Mariman, E.C.; Sulistyoningrum, D.C.; Huriyati, E.; Lee, Y.Y.; Wan Muda, W.A.M. Dietary Inflammatory Index Score and Its Association with Body Weight, Blood Pressure, Lipid Profile, and Leptin in Indonesian Adults. Nutrients 2019, 11, 148.

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