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Nutrients 2019, 11(1), 149; https://doi.org/10.3390/nu11010149

Limited Effects of Low-to-Moderate Aerobic Exercise on the Gut Microbiota of Mice Subjected to a High-Fat Diet

1
Post-Graduation Program in Physical Education, Catholic University of Brasilia, Brasilia 71966-700, DF, Brazil
2
Center for Proteomic and Biochemical Analysis, Post-Graduation in Genomic and Biotechnology Sciences, Catholic University of Brasilia, Brasília 71966-700, DF, Brazil
3
University Center—UDF, Research Group of Molecular Exercise Physiology, Brasilia 70390-045, DF, Brazil
4
S-Inova Biotech, Catholic University Dom Bosco, Biotechnology Program, Campo Grande, 79000-000, MS, Brazil
5
Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro Oeste—PPGSD, Faculdade de Medicina—FAMED, Universidade Federal de Mato Grosso do Sul, Campo Grande 71966-700, MS, Brazil
*
Author to whom correspondence should be addressed.
Received: 6 December 2018 / Revised: 26 December 2018 / Accepted: 3 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Gut Microbiota and Obesity)
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Abstract

Several studies have indicated that diet and exercise may modulate the gut microbiota in obese subjects. Both interventions were shown to alter the microbiota orthogonally. However, this relationship has not been fully explored. This study analyzed the effects of low-to-moderate aerobic training on the fecal microbiota of mice subjected to a high-fat diet (HFD). Here, 40 male mice (C57Bl/6) were divided into two groups with standard diet (SD; 12.4% lipid) and HFD (60.3% lipid) for four months. These groups were divided into four, named SD control, HF control, SD trained and HF trained. All animals were submitted to an incremental test to estimate low-to-moderate maximum speed. Training consisted of 30 min·day−1, 5 days/week, for 8 weeks. The HFD increased the body weight (p < 0.0001) and adiposity index (p < 0.05). HFD also negatively influenced performance in exercise training. Moreover, the diversity of gut microbiota was reduced by the HFD in all groups. A low-to-moderate exercise was ineffective in modulating the gut microbiota composition in mice subjected to HFD. These findings suggest that two months of low-to-moderate exercise does not achieve a preponderant modulatory effect on shaping microbiota when submitted to the high-fat diet. View Full-Text
Keywords: gut microbiota; obesity; low-to-moderate intensity; physical activity; diet gut microbiota; obesity; low-to-moderate intensity; physical activity; diet
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ribeiro, F.M.; Ribeiro, C.F.A.; Garcia, A.C.M.; Castro, A.P.; Almeida, J.A.; Franco, O.L.; Petriz, B.A. Limited Effects of Low-to-Moderate Aerobic Exercise on the Gut Microbiota of Mice Subjected to a High-Fat Diet. Nutrients 2019, 11, 149.

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