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Nutrients
Volume 10
Issue 4
10.3390/nu10040484
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Article

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

by
M. Dolores Paredes
1,
Paola Romecín
1,
Noemí M. Atucha
1,
Francisco O’Valle
2,
Julián Castillo
3,
M. Clara Ortiz
1 and
Joaquín García-Estañ
1,*
1
Departamento de Fisiología, Facultad de Medicina & Instituto Murciano de Investigaciones Biosanitarias, Universidad de Murcia, 30120 Murcia, Spain
2
Departamento de Anatomía Patológica, Facultad de Medicina, IBIMER, ibs.Granada, Universidad de Granada, 18011 Granada, Spain
3
Instituto Universitario de Envejecimiento & Research and Development Department, Nutrafur SA-FRUTAROM Group, 30820 Alcantarilla (Murcia), Spain
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(4), 484; https://doi.org/10.3390/nu10040484
Submission received: 7 March 2018 / Revised: 2 April 2018 / Accepted: 10 April 2018 / Published: 13 April 2018
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Abstract

Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.
Keywords: flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine

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MDPI and ACS Style

Paredes, M.D.; Romecín, P.; Atucha, N.M.; O’Valle, F.; Castillo, J.; Ortiz, M.C.; García-Estañ, J. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients 2018, 10, 484. https://doi.org/10.3390/nu10040484

AMA Style

Paredes MD, Romecín P, Atucha NM, O’Valle F, Castillo J, Ortiz MC, García-Estañ J. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients. 2018; 10(4):484. https://doi.org/10.3390/nu10040484

Chicago/Turabian Style

Paredes, M. Dolores, Paola Romecín, Noemí M. Atucha, Francisco O’Valle, Julián Castillo, M. Clara Ortiz, and Joaquín García-Estañ. 2018. "Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats" Nutrients 10, no. 4: 484. https://doi.org/10.3390/nu10040484

APA Style

Paredes, M. D., Romecín, P., Atucha, N. M., O’Valle, F., Castillo, J., Ortiz, M. C., & García-Estañ, J. (2018). Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients, 10(4), 484. https://doi.org/10.3390/nu10040484

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