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Thalassemia Reports, Volume 13, Issue 3

September 2023 - 4 articles

Cover Story: Sickle Cell Disease, a genetic ailment, transforms red blood cells, thereby diminishing their oxygen-carrying ability. Further, a dysfunctional spleen in SCD leads to weakened immunity against infection by encapsulated bacteria. In particular, young children face grave health challenges due to their high susceptibility to infections, heightened by environmental hazards such as pollution and second-hand smoke. The spectrum of infections spans from sepsis to bone inflammation, with COVID-19 adding a new layer of complexity. However, tools like Sickle SCAN^® diagnostics and novel molecular-level therapeutics promise superior care. Further, comprehensive analysis of the genetic variations, alongside strategic interventions, has illuminated a hopeful path. Thus, with the progress of science, we may edge closer to ameliorating the burdens of SCD, championing better lives for these patients. View this paper

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Articles (4)

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Review

9 Citations

9,618 Views

24 Pages

Infection and Potential Challenge of Childhood Mortality in Sickle Cell Disease: A Comprehensive Review of the Literature from a Global Perspective

Tarun Sahu,
Babita Pande,
Henu Kumar Verma,
L V K S Bhaskar,
Meenakshi Sinha,
Ramanjan Sinha and
Pasupuleti Visweswara Rao

Thalass. Rep.2023, 13(3), 206-229;https://doi.org/10.3390/thalassrep13030019

30 August 2023

Sickle cell disease (SCD) is a complex genetic disorder associated with multiple clinical manifestations, including increased susceptibility to bacterial and viral infections. This review article presents a comprehensive analysis of the current liter...

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Review

11 Citations

4,750 Views

11 Pages

Association between Glomerular Filtration Rate and β-Thalassemia Major: A Systematic Review and Meta-Analysis

Shahad Saif Khandker,
Nurani Jannat,
Deepannita Sarkar,
Alif Hasan Pranto,
Ismoth Ara Hoque,
Jemema Zaman,
Md. Nizam Uddin and
Ehsan Suez

Thalass. Rep.2023, 13(3), 195-205;https://doi.org/10.3390/thalassrep13030018

29 August 2023

Thalassemia is one of the most prevalent genetic disorders worldwide and has previously been found to have an association with several physiological and organ complications. Several studies have found both its positive and inverse correlation with th...

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Review

13 Citations

11,018 Views

16 Pages

Understanding the Intricacies of Iron Overload Associated with β-Thalassemia: A Comprehensive Review

Subhangi Basu,
Motiur Rahaman,
Tuphan Kanti Dolai,
Praphulla Chandra Shukla and
Nishant Chakravorty

Thalass. Rep.2023, 13(3), 179-194;https://doi.org/10.3390/thalassrep13030017

3 July 2023

β-thalassemia, a congenital genetic hematological disorder characterized by the decrease or absence of β-globin chains, leads to a decrease in levels of Hemoglobin A. The affected individuals can be categorized into two cohorts based on tra...

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Article

2 Citations

3,370 Views

14 Pages

Molecular Epidemiology of HCV Infection among Multi-Transfused β-Thalassemia Patients in Eastern India: A Six-Year Observation

Supradip Dutta,
Aritra Biswas,
Sagnik Bakshi,
Promisree Choudhury,
Raina Das,
Shreyasi Nath,
Prosanto Chowdhury,
Maitreyee Bhattacharyya,
Sharmistha Chakraborty and
Shanta Dutta
+ 1 author

Thalass. Rep.2023, 13(3), 165-178;https://doi.org/10.3390/thalassrep13030016

25 June 2023

Background: HCV infection is very common in multi-transfused β-thalassemia patients who need regular blood transfusions. Aim: The study was conducted to determine the epidemiology of HCV in multi-transfused β-thalassemia patients in West Be...

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