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Hematology Reports, Volume 16, Issue 1

2024 March - 17 articles

Cover Story: Exploring hematological sequelae of SARS-CoV-2 in the post-pandemic era provides crucial insights into the potential long-term consequences of COVID-19 on the hematopoietic system. Moreover, the connection between COVID-19 and bone marrow failure is an emerging area of interest, as the number of reports of acquired pancytopenia after infection continues to grow globally. This case report highlights two cases of pancytopenia after recovery from mild COVID-19 infection, presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. Along with a review of similar reports of acquired bone marrow failure syndrome cases after COVID-19, we discuss the potential viral mechanisms of immune-mediated bone marrow failure and the implications of the SARS-CoV-2 virus on PNH clone expansion. View this paper
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Articles (17)

  • Review
  • Open Access
3 Citations
4,218 Views
15 Pages

Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview

  • Antonella Argentiero,
  • Alessandro Andriano,
  • Donatello Marziliano and
  • Vanessa Desantis

21 March 2024

Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating from B, T, or NK lymphocytes. They represent approximately 4–5% of new cancer cases and are classified according to the revised WHO syst...

  • Review
  • Open Access
13 Citations
6,998 Views
13 Pages

Drug–Drug Interactions of FXI Inhibitors: Clinical Relevance

  • Nicola Ferri,
  • Elisa Colombo and
  • Alberto Corsini

21 March 2024

Inhibitors of the factor FXI represent a new class of anticoagulant agents that are facing clinical approval for the treatment of acute coronary syndrome (ACS), venous thromboembolism (VTE), and stroke prevention of atrial fibrillation (AF). These ne...

  • Article
  • Open Access
6 Citations
2,584 Views
11 Pages

The Cardiovascular Event Risk Associated with Tyrosine Kinase Inhibitors and the Lipid Profile in Patients with Chronic Myeloid Leukemia

  • María Nieves Saez Perdomo,
  • Ruth Stuckey,
  • Elena González-Pérez,
  • Santiago Sánchez-Sosa and ,
  • Paula Estupiñan-Cabrera,
  • Sunil Lakhwani Lakhwani,
  • José David González San Miguel,
  • Nuria Hernanz Soler,
  • Marina Gordillo and
  • María Teresa Gómez-Casares
  • + 11 authors+ 6 authors

12 March 2024

Background: Second- and third-generation tyrosine kinase inhibitors (TKIs) are now available to treat chronic-phase chronic myeloid leukemia (CP-CML) in the first and second line. However, vascular adverse events (VAEs) have been reported for patient...

  • Case Report
  • Open Access
2,460 Views
8 Pages

Factor VII Deficiency in Systemic Mastocytosis with an Associated Myeloid Neoplasm

  • Giorgio Rosati,
  • Sofia Camerlo,
  • Alessandro Fornari,
  • Valerio Marci and ,
  • Barbara Montaruli and
  • Alessandro Morotti
  • + 1 author+ 0 author

12 March 2024

Factor VII (FVII) deficiency is a rare bleeding disorder that can be classified as congenital or acquired, and the majority of acquired cases are due to vitamin K deficiency or liver disease. Isolated acquired FVII deficiency is a rare occurrence and...

(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Congenital and Acquired Haemorrhagic Disorders, Thromboembolic Disease and Platelet Disorders)
  • Case Report
  • Open Access
3 Citations
4,363 Views
7 Pages

Uncommon Presentation of Sarcoidosis with Severe Thrombocytopenia and Hemorrhagic Diathesis

  • Dorela Lame,
  • Michelangelo Pianelli,
  • Shahram Kordasti,
  • Erika Morsia and ,
  • Attilio Olivieri and
  • Antonella Poloni
  • + 1 author+ 0 author

Sarcoidosis, a multi-organ system disease, often presents insidiously. Thrombocytopenia in sarcoidosis is frequent because of hypersplenism, granulomas infiltrating the bone marrow, or immune thrombocytopenia (ITP). The diagnosis of ITP relies on exc...

  • Article
  • Open Access
2 Citations
2,267 Views
11 Pages

Impact of Skeletal Muscle Depletion on Patients with Myelodysplastic Syndrome Treated with Azacitidine

  • Eri Takada,
  • Nobuhiko Nakamura,
  • Yuto Kaneda,
  • Kenji Fukuno and ,
  • Shin Lee,
  • Kei Fujita,
  • Tetsuji Morishita,
  • Yoshikazu Ikoma,
  • Takuro Matsumoto and
  • Masahito Shimizu
  • + 11 authors+ 6 authors

28 February 2024

Background: Azacitidine (AZA) is the standard treatment for patients with high-risk myelodysplastic syndromes (MDS). The impact of skeletal muscle depletion (SMD), which is associated with outcomes of hematological malignancies, on the clinical cours...

  • Case Report
  • Open Access
3 Citations
3,866 Views
8 Pages

Primary Bone Lymphoma of the Scapula

  • Josip Lovaković,
  • Inga Mandac Smoljanović,
  • Andro Matković and
  • Tomislav Smoljanović

28 February 2024

Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. The presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring fingers. The 45-year-old man underwent several ra...

  • Case Report
  • Open Access
3 Citations
4,635 Views
8 Pages

Successful Bone Marrow Transplantation in a Patient with Acute Myeloid Leukemia Developed from Severe Congenital Neutropenia Using Modified Chemotherapy and Conditioning Regimen for Leukemia

  • Risa Matsumura,
  • Shinji Mochizuki,
  • Yusuke Morishita,
  • Hiroko Hayakawa and ,
  • Shuhei Karakawa,
  • Hiroshi Kawaguchi,
  • Satoshi Okada,
  • Nobuyuki Hyakuna and
  • Masao Kobayashi
  • + 4 authors+ 0 author

26 February 2024

Severe congenital neutropenia (SCN) is characterized by chronic neutropenia with recurrent infections from early infancy and a predisposition to myelodysplastic syndrome/acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation...

  • Article
  • Open Access
7 Citations
3,496 Views
9 Pages

Prevalence, Outcomes and Impact of Disease-Related Complications in the Survival of Multiple Myeloma Patients

  • Wachiralak Tothong,
  • Adisak Tantiworawit,
  • Lalita Norasetthada,
  • Chatree Chai-Adisaksopha and ,
  • Teerachat Punnachet,
  • Nonthakorn Hantrakun,
  • Pokpong Piriyakhuntorn,
  • Thanawat Rattanathammethee,
  • Sasinee Hantrakool and
  • Ekarat Rattarittamrong
  • + 5 authors+ 0 author

21 February 2024

There are limited data regarding the impact of disease-related complications on the survival of multiple myeloma (MM) patients. The primary objective of this study was to determine the prevalence of disease-related complications, including hypercalce...

  • Article
  • Open Access
4 Citations
5,347 Views
13 Pages

Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study

  • Masaya Morimoto,
  • Yuma Yokoya,
  • Kikuaki Yoshida,
  • Hideki Kosako and ,
  • Yoshikazu Hori,
  • Toshiki Mushino,
  • Shinobu Tamura,
  • Reiko Ito,
  • Ryosuke Koyamada and
  • Sachiko Ohde
  • + 8 authors+ 3 authors

7 February 2024

Febrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN...

  • Article
  • Open Access
13 Citations
3,687 Views
13 Pages

The Gut Microbiome Correlated to Chemotherapy Efficacy in Diffuse Large B-Cell Lymphoma Patients

  • Zhuo-Fan Xu,
  • Li Yuan,
  • Yan Zhang,
  • Wei Zhang and ,
  • Chong Wei,
  • Wei Wang,
  • Danqing Zhao,
  • Daobin Zhou and
  • Jingnan Li
  • + 4 authors+ 0 author

22 January 2024

The gut microbiome (GMB) has been extensively reported to be associated with the development and prognosis of human diseases. This study aims to investigate the relationship between GMB composition and chemotherapy efficacy in diffuse large B-cell ly...

  • Article
  • Open Access
17 Citations
7,046 Views
13 Pages

Survival Outcomes of Patients with Mantle Cell Lymphoma: A Retrospective, 15-Year, Real-Life Study

  • Emanuele Cencini,
  • Natale Calomino,
  • Marta Franceschini,
  • Andreea Dragomir and ,
  • Sara Fredducci,
  • Beatrice Esposito Vangone,
  • Giulia Lucco Navei,
  • Alberto Fabbri and
  • Monica Bocchia
  • + 4 authors+ 0 author

18 January 2024

Mantle cell lymphoma (MCL) prognosis has significantly improved in recent years; however, the possible survival benefit of new treatment options should be evaluated outside of clinical trials. We investigated 73 consecutive MCL patients managed from...

  • Case Report
  • Open Access
2 Citations
5,774 Views
8 Pages

17 January 2024

We report two cases of pancytopenia in patients after recovering from a mild COVID-19, now presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. These cases illustrate a common pathway whereby a viral trigger causes the clonal...

(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Congenital and Acquired Haemorrhagic Disorders, Thromboembolic Disease and Platelet Disorders)
  • Review
  • Open Access
11 Citations
3,931 Views
10 Pages

Emerging Role of [18F]FLT PET/CT in Lymphoid Malignancies: A Review of Clinical Results

  • Anna Giulia Nappi,
  • Giulia Santo,
  • Lorenzo Jonghi-Lavarini,
  • Alberto Miceli and ,
  • Achille Lazzarato,
  • Flavia La Torre,
  • Francesco Dondi and
  • Joana Gorica
  • + 3 authors+ 0 author

11 January 2024

Fluorine-18 fluorodeoxyglucose ([18F]FDG) is nowadays the leading positron emission tomography (PET) tracer for routine clinical work-ups in hematological malignancies; however, it is limited by false positive findings. Notably, false positives can o...

  • Case Report
  • Open Access
11 Citations
4,300 Views
10 Pages

Plasmacytoma in the Maxillary Jaw: A Diagnostic and Therapeutic Challenge

  • Sara Bernardi,
  • Serena Bianchi,
  • Ettore Lupi,
  • Davide Gerardi and ,
  • Guido Macchiarelli and
  • Giuseppe Varvara
  • + 1 author+ 0 author

Plasmacytoma is a neoplastic disorder originating from plasma cells, with bone and soft tissue being common sites of manifestation. This report presents the clinical and radiological findings of a 65-year-old female patient who presented with an exop...

  • Case Report
  • Open Access
3 Citations
3,190 Views
11 Pages

28 December 2023

Post-transplant lymphoproliferative disease is a rare disorder with an annual incidence of 0.5% to 3.7%. Development of this disorder carries with it a poor prognosis. In this report, we describe a rare case of post-transplant primary cutaneous T-cel...

  • Article
  • Open Access
2 Citations
2,200 Views
10 Pages

22 December 2023

Quality of life (QOL) must be carefully monitored in older patients with lymphoma who are suitable for chemotherapy, but few reports have assessed QOL in older patients who received reduced-intensity chemotherapy. This study investigated QOL in patie...

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Hematol. Rep. - ISSN 2038-8330