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Hematology Reports, Volume 16, Issue 1

March 2024 - 17 articles

Cover Story: Exploring hematological sequelae of SARS-CoV-2 in the post-pandemic era provides crucial insights into the potential long-term consequences of COVID-19 on the hematopoietic system. Moreover, the connection between COVID-19 and bone marrow failure is an emerging area of interest, as the number of reports of acquired pancytopenia after infection continues to grow globally. This case report highlights two cases of pancytopenia after recovery from mild COVID-19 infection, presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. Along with a review of similar reports of acquired bone marrow failure syndrome cases after COVID-19, we discuss the potential viral mechanisms of immune-mediated bone marrow failure and the implications of the SARS-CoV-2 virus on PNH clone expansion. View this paper
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Articles (17)

  • Review
  • Open Access
3 Citations
3,204 Views
15 Pages

Navigating Lymphomas through BCR Signaling and Double-Hit Insights: Overview

  • Antonella Argentiero,
  • Alessandro Andriano,
  • Donatello Marziliano and
  • Vanessa Desantis

21 March 2024

Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating from B, T, or NK lymphocytes. They represent approximately 4–5% of new cancer cases and are classified according to the revised WHO syst...

  • Review
  • Open Access
9 Citations
4,860 Views
13 Pages

Drug–Drug Interactions of FXI Inhibitors: Clinical Relevance

  • Nicola Ferri,
  • Elisa Colombo and
  • Alberto Corsini

21 March 2024

Inhibitors of the factor FXI represent a new class of anticoagulant agents that are facing clinical approval for the treatment of acute coronary syndrome (ACS), venous thromboembolism (VTE), and stroke prevention of atrial fibrillation (AF). These ne...

  • Article
  • Open Access
3 Citations
2,058 Views
11 Pages

The Cardiovascular Event Risk Associated with Tyrosine Kinase Inhibitors and the Lipid Profile in Patients with Chronic Myeloid Leukemia

  • María Nieves Saez Perdomo,
  • Ruth Stuckey,
  • Elena González-Pérez,
  • Santiago Sánchez-Sosa,
  • Paula Estupiñan-Cabrera,
  • Sunil Lakhwani Lakhwani,
  • José David González San Miguel,
  • Nuria Hernanz Soler,
  • Marina Gordillo and
  • Gloria González Brito
  • + 6 authors

12 March 2024

Background: Second- and third-generation tyrosine kinase inhibitors (TKIs) are now available to treat chronic-phase chronic myeloid leukemia (CP-CML) in the first and second line. However, vascular adverse events (VAEs) have been reported for patient...

  • Case Report
  • Open Access
1,955 Views
8 Pages

Factor VII Deficiency in Systemic Mastocytosis with an Associated Myeloid Neoplasm

  • Giorgio Rosati,
  • Sofia Camerlo,
  • Alessandro Fornari,
  • Valerio Marci,
  • Barbara Montaruli and
  • Alessandro Morotti

12 March 2024

Factor VII (FVII) deficiency is a rare bleeding disorder that can be classified as congenital or acquired, and the majority of acquired cases are due to vitamin K deficiency or liver disease. Isolated acquired FVII deficiency is a rare occurrence and...

  • Case Report
  • Open Access
1 Citations
2,847 Views
7 Pages

Uncommon Presentation of Sarcoidosis with Severe Thrombocytopenia and Hemorrhagic Diathesis

  • Dorela Lame,
  • Michelangelo Pianelli,
  • Shahram Kordasti,
  • Erika Morsia,
  • Attilio Olivieri and
  • Antonella Poloni

Sarcoidosis, a multi-organ system disease, often presents insidiously. Thrombocytopenia in sarcoidosis is frequent because of hypersplenism, granulomas infiltrating the bone marrow, or immune thrombocytopenia (ITP). The diagnosis of ITP relies on exc...

  • Article
  • Open Access
1 Citations
1,749 Views
11 Pages

Impact of Skeletal Muscle Depletion on Patients with Myelodysplastic Syndrome Treated with Azacitidine

  • Eri Takada,
  • Nobuhiko Nakamura,
  • Yuto Kaneda,
  • Kenji Fukuno,
  • Shin Lee,
  • Kei Fujita,
  • Tetsuji Morishita,
  • Yoshikazu Ikoma,
  • Takuro Matsumoto and
  • Hiroshi Nakamura
  • + 6 authors

28 February 2024

Background: Azacitidine (AZA) is the standard treatment for patients with high-risk myelodysplastic syndromes (MDS). The impact of skeletal muscle depletion (SMD), which is associated with outcomes of hematological malignancies, on the clinical cours...

  • Case Report
  • Open Access
1 Citations
2,990 Views
8 Pages

Primary Bone Lymphoma of the Scapula

  • Josip Lovaković,
  • Inga Mandac Smoljanović,
  • Andro Matković and
  • Tomislav Smoljanović

28 February 2024

Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. The presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring fingers. The 45-year-old man underwent several ra...

  • Case Report
  • Open Access
2 Citations
2,920 Views
8 Pages

Successful Bone Marrow Transplantation in a Patient with Acute Myeloid Leukemia Developed from Severe Congenital Neutropenia Using Modified Chemotherapy and Conditioning Regimen for Leukemia

  • Risa Matsumura,
  • Shinji Mochizuki,
  • Yusuke Morishita,
  • Hiroko Hayakawa,
  • Shuhei Karakawa,
  • Hiroshi Kawaguchi,
  • Satoshi Okada,
  • Nobuyuki Hyakuna and
  • Masao Kobayashi

26 February 2024

Severe congenital neutropenia (SCN) is characterized by chronic neutropenia with recurrent infections from early infancy and a predisposition to myelodysplastic syndrome/acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation...

  • Article
  • Open Access
3 Citations
2,300 Views
9 Pages

Prevalence, Outcomes and Impact of Disease-Related Complications in the Survival of Multiple Myeloma Patients

  • Wachiralak Tothong,
  • Adisak Tantiworawit,
  • Lalita Norasetthada,
  • Chatree Chai-Adisaksopha,
  • Teerachat Punnachet,
  • Nonthakorn Hantrakun,
  • Pokpong Piriyakhuntorn,
  • Thanawat Rattanathammethee,
  • Sasinee Hantrakool and
  • Ekarat Rattarittamrong

21 February 2024

There are limited data regarding the impact of disease-related complications on the survival of multiple myeloma (MM) patients. The primary objective of this study was to determine the prevalence of disease-related complications, including hypercalce...

  • Article
  • Open Access
1 Citations
3,666 Views
13 Pages

Predictive Model for Occurrence of Febrile Neutropenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma: A Multicenter, Retrospective, Observational Study

  • Masaya Morimoto,
  • Yuma Yokoya,
  • Kikuaki Yoshida,
  • Hideki Kosako,
  • Yoshikazu Hori,
  • Toshiki Mushino,
  • Shinobu Tamura,
  • Reiko Ito,
  • Ryosuke Koyamada and
  • Takuya Yamashita
  • + 3 authors

7 February 2024

Febrile neutropenia (FN) is a major concern in patients undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL); however, the overall risk of FN is difficult to assess. This study aimed to develop a model for predicting the occurrence of FN...

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Hematol. Rep. - ISSN 2038-8330