You are currently viewing a new version of our website. To view the old version click .

Hematology Reports, Volume 15, Issue 1

March 2023 - 23 articles

Cover Story: The hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor reduces HIF-α for degradation purposes, allows HIF-α and HIF-β to translocate to the renal erythropoietin (EPO)-producing (REP) cell nucleus, and promotes transcription of EPO, the primary regulator of red blood cell (RBC) production. The sodium–glucose cotransporter 2 (SGLT2) inhibitor plays an important role in the reabsorption of glucose, reduces albuminuria, and promotes the glomerular filtration rate, which is associated with chronic kidney disease (CKD). In addition, CKD-related anemia promotes endogenous EPO production. We found that an HIF-PH inhibitor combined with an SGLT2 inhibitor is an effective form of treatment for low-risk myelodysplastic syndrome-related anemia. Further studies are required to clarify these synergistic effects. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (23)

  • Case Report
  • Open Access
1 Citations
2,401 Views
5 Pages

22 March 2023

Recently, Brentuximab Vedotin (BV) has emerged as an important therapy not only for Hodgkin’s Lymphoma, but also for CD30-positive T cell lymphomas. Although anemia and thrombocytopenia are common myelosuppressive side effects, to our knowledge...

  • Case Report
  • Open Access
2 Citations
2,407 Views
8 Pages

Extramedullary T-lymphoblastic Crisis in a Myelodysplastic/Myeloproliferative Neoplasm with a t(12;22)/MN1::ETV6 Translocation

  • Ana Carolina Freitas,
  • Tiago Maia,
  • Joana Desterro,
  • Francesca Pierdomenico,
  • Albertina Nunes,
  • Isabelina Ferreira,
  • José Cabeçadas and
  • Maria Gomes da Silva

14 March 2023

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are not a single disease, but rather a heterogenous group of entities which are increasingly subclassified according to recurrent genetic abnormalities. Chromosomal translocations involving menin...

  • Article
  • Open Access
9 Citations
11,200 Views
11 Pages

Reticulocyte Hemoglobin as a Screening Test for Iron Deficiency Anemia: A New Cut-Off

  • Abdullah I. Aedh,
  • Mohamed S. M. Khalil,
  • Alaa S. Abd-Elkader,
  • Mohamed M. El-Khawanky,
  • Hamdan M. Alshehri,
  • Amr Hussein,
  • Ali A. Lafi Alghamdi and
  • Abdulkarim Hasan

14 March 2023

Introduction: Latent iron deficiency (LID), in which iron stores in the body are depleted without incidental anemia, poses a key diagnostic challenge. Reticulocyte hemoglobin content (Ret-Hb) is directly correlated with the functionally available iro...

  • Case Report
  • Open Access
5 Citations
4,463 Views
13 Pages

Mutational Profile and Pathological Features of a Case of Interleukin-10 and RGS1-Positive Spindle Cell Variant Diffuse Large B-Cell Lymphoma

  • Joaquim Carreras,
  • Yara Yukie Kikuti,
  • Masashi Miyaoka,
  • Shinichiro Hiraiwa,
  • Sakura Tomita,
  • Haruka Ikoma,
  • Yusuke Kondo,
  • Atsushi Ito,
  • Shunsuke Nagase and
  • Hisanobu Miura
  • + 5 authors

12 March 2023

Diffuse large B-cell lymphoma with spindle cell morphology is a rare variant. We present the case of a 74-year-old male who initially presented with a right supraclavicular (lymph) node enlargement. Histological analysis showed a proliferation of spi...

  • Case Report
  • Open Access
4 Citations
2,807 Views
8 Pages

Although daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, and dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, have been approved for the treatment of renal anemia in Japan, their efficacy and safety for patients aged 8...

  • Case Report
  • Open Access
4 Citations
4,865 Views
8 Pages

Myeloproliferative neoplasms (MPN) such as essential thrombocythemia (ET) and polycythemia vera (PV) are rare during pregnancy. However, they are harmful because they are associated with an increased risk of thromboembolic, hemorrhagic, or microcircu...

  • Case Report
  • Open Access
2 Citations
2,753 Views
6 Pages

Constrictive Pericarditis–A Cloak Camouflaging Lymphoma

  • Delanthabettu Venugopala,
  • Nikhil Victor Dsouza,
  • Vishak Acharya,
  • Maneesh Rai,
  • Chaithra Gowthuvalli Venkataramana and
  • Stergios Boussios

Non-Hodgkin’s lymphoma presenting as a primary cardiac lymphoma (PCL) is extremely unusual. Having a predilection for the right side of the heart and accounting for 1% of all cardiac tumours, the difficulty in diagnosing the lesion, owing to th...

  • Article
  • Open Access
1 Citations
2,325 Views
9 Pages

Neoplastic and Autoimmune Comorbidities in Patients with Primary Cutaneous B-Cell Lymphoma

  • Roberto Mazzetto,
  • Jacopo Tartaglia,
  • Alvise Sernicola and
  • Mauro Alaibac

27 February 2023

Primary cutaneous B-cell lymphomas (PCBCLs) constitute a rare subset of non-Hodgkin lymphoma (NHL), with distinctive clinical and biological characteristics. The risk of autoimmune or neoplastic comorbidities in subjects with NHL has been extensively...

  • Brief Report
  • Open Access
5 Citations
4,079 Views
6 Pages

Frail Multiple Myeloma Patients Deserve More Than Just a Score

  • Hannah Louise Miller and
  • Faye Amelia Sharpley

21 February 2023

Frailty is a hot topic in the field of multiple myeloma (MM). Clinicians have realised that frail myeloma patients can struggle with treatment, resulting in dose reductions and treatment discontinuation, which risk shorter progression-free and overal...

  • Review
  • Open Access
21 Citations
18,167 Views
21 Pages

Haemophilia A: A Review of Clinical Manifestations, Treatment, Mutations, and the Development of Inhibitors

  • Samuel Sarmiento Doncel,
  • Gina Alejandra Díaz Mosquera,
  • Javier Mauricio Cortes,
  • Carol Agudelo Rico,
  • Francisco Javier Meza Cadavid and
  • Ronald Guillermo Peláez

16 February 2023

The purpose of this narrative review was to provide an overview that allows readers to improve their understanding of hemophilia A, which is considered a genetic disease with a high impact on the quality of life of people who suffer from it is consid...

of 3

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Hematol. Rep. - ISSN 2038-8330