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Pediatric Reports, Volume 15, Issue 3

2023 September - 16 articles

Cover Story: Clinicians attempt to avoid antibiotic use unless there are convincing signs of infection. The aims of this study were to report the ontogeny of biomarkers for inflammation among 142 infants born at 22 to 32 weeks of gestation and contextualize the levels with common etiologies of preterm delivery. Independent of gestational age, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and C-reactive protein (CRP) sharply declined following delivery. MCP-1 was increased in infants exposed to preeclampsia but decreased in those exposed to chorioamnionitis. CRP was increased in infants with funisitis, but it increased a day later than IL-6 in those with sepsis. Our results reveal unique biomarker profiles in infants exposed to distinct perinatal complications with implications for antibiotic stewardship and mechanistic investigations. View this paper
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Articles (16)

  • Case Report
  • Open Access
10 Citations
2,799 Views
11 Pages

Prechemotherapy Transperitoneal Robotic-Assisted Partial Nephrectomy (RAPN) for a Wilms Tumor: Surgical and Oncological Outcomes in a Four-Year-Old Patient

  • Marcello Della Corte,
  • Elisa Cerchia,
  • Marco Oderda,
  • Paola Quarello,
  • Franca Fagioli,
  • Paolo Gontero and
  • Simona Gerocarni Nappo

21 September 2023

Background: Wilms tumor (WT) is the most frequent renal tumor in children. The SIOP-UMBRELLA Guidelines allow for nephron-sparing surgery (NSS) in syndromic patients, as well as in cases of small (<300 mL) non-syndromic unilateral WTs, without lym...

  • Article
  • Open Access
15 Citations
5,569 Views
12 Pages

Early Diagnostic Markers of Late-Onset Neonatal Sepsis

  • Preslava Gatseva,
  • Alexander Blazhev,
  • Zarko Yordanov and
  • Victoria Atanasova

20 September 2023

Objective: Early diagnosis of nosocomial infections in newborns is a great challenge, because in the initial phase of systemic infection, clinical symptoms are often non-specific, and routinely used hematological markers are not sufficiently informat...

  • Case Report
  • Open Access
1 Citations
4,144 Views
7 Pages

Diagnostic Significance of Absence of Post-Feeding Contraction of the Gallbladder in Biliary Atresia: Two Case Reports

  • Masahiko Kosuga,
  • Yoshimitsu Fujii,
  • Takashi Doi,
  • Kazunari Kaneko and
  • Raoul Breugelmans

6 September 2023

Ultrasonography is an essential part of the diagnostic process of biliary atresia (BA). The characteristic findings of BA include a hilar hyperechoic zone, the triangular cord sign (TCS), an absence of gallbladder contraction after feeding, and gallb...

  • Case Report
  • Open Access
1 Citations
2,970 Views
9 Pages

SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children (MIS-C): A Case Report from Iraq

  • Ruwaid Behnam Y. Al-Simaani,
  • Lika’a Fasih Y. Al-Kzayer,
  • Kenan Hussien Ali,
  • Mouroge H. Al-Ani and
  • Yozo Nakazawa

4 September 2023

The novel coronavirus disease (COVID-19) continues to evolve. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated multisystem inflammatory syndrome in children (MIS-C) is a rare post-COVID-19 complication that affects children wit...

(This article belongs to the Collection COVID-19: What Happens in Pediatric Research in the Era of Pandemic)
  • Systematic Review
  • Open Access
3,194 Views
20 Pages

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis

  • Matteo Riccò,
  • Ilaria Zanella,
  • Elia Satta,
  • Silvia Ranzieri,
  • Silvia Corrado,
  • Federico Marchesi and
  • Simona Peruzzi

1 September 2023

Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (<18-year-old)...

  • Article
  • Open Access
4 Citations
3,177 Views
10 Pages

Learning Italian as a Second Language in a Sample of Ukrainian Children: A Game-Based Learning Approach

  • Alessandro Frolli,
  • Francesco Cerciello,
  • Clara Esposito,
  • Mariagrazia Russo and
  • Fabio Bisogni

18 August 2023

Game-based learning is an educational approach aimed at acquiring knowledge through the use of play. There are various studies that note the effectiveness of playing as an educational tool and the use of digital platforms as a tool that can increase...

  • Case Report
  • Open Access
1 Citations
7,800 Views
8 Pages

11 August 2023

Background: Self-limited epilepsy with autonomic seizures (SeLEAS), formerly known as Panayiotopoulos syndrome (PS), is a common multifocal autonomic childhood epileptic syndrome. SeLEAS affects 6% of children in between the ages of 1 and 15 years wh...

  • Article
  • Open Access
3 Citations
3,175 Views
11 Pages

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection

  • Jordan T. Ewald,
  • Baiba Steinbrekera,
  • Jennifer R. Bermick,
  • Donna A. Santillan,
  • Tarah T. Colaizy,
  • Mark K. Santillan and
  • Robert D. Roghair

10 August 2023

Preterm delivery can be precipitated by preeclampsia or infection, and preterm infants are at heightened risk of postnatal infection. Little is known about the ontogeny of inflammatory biomarkers in extremely preterm infants. We hypothesized that sus...

  • Systematic Review
  • Open Access
13 Citations
4,310 Views
21 Pages

9 August 2023

Rare Diseases (RDs) in adolescents are characterized by low frequency and clinical heterogeneity, are chronic and deliberating and demand a multidisciplinary approach as well as costly and specialized treatments. Comprehending patients’ and par...

  • Article
  • Open Access
6 Citations
3,493 Views
10 Pages

Healthcare Experience of Pediatric Patients with Autism Spectrum Disorders in Saudi Arabia: A Cross-Sectional Study

  • Basma Al-Jabri,
  • Sara Alnuwaiser,
  • Haifa Abdulghaffar,
  • Rahaf Almuhanna,
  • Shaimaa Salaam,
  • Raval Brika,
  • Alia Addas and
  • Hala Bedaiwi

7 August 2023

Children with autism spectrum disorder (ASD) face several challenges in the healthcare setting. This study defines the challenges experienced by children with autism in hospitals in Saudi Arabia. A cross-sectional study was conducted using a question...

(This article belongs to the Section Pediatric Psychology)
  • Case Report
  • Open Access
14 Citations
7,633 Views
10 Pages

Congenital Diaphragmatic Eventration in the Neonatal Period: Systematic Review of the Literature and Report of a Rare Case Presenting with Gastrointestinal Disorders

  • Aikaterini Konstantinidi,
  • Paraskevi Liakou,
  • Paschalia Kopanou Taliaka,
  • Maria Lampridou,
  • Nicoletta Kalatzi,
  • Ierotheos Loukas,
  • Evangelia-Filothei Tavoulari,
  • Konstantinos Mitropoulos,
  • Konstantinos Koulopoulos and
  • Rozeta Sokou

26 July 2023

Background: The term congenital diaphragmatic eventration (CDE) refers to an anatomical abnormality of the diaphragm. It is a very rare condition; however, early and prompt diagnosis is of very great importance due to possible life-threatening compli...

  • Systematic Review
  • Open Access
11 Citations
5,942 Views
11 Pages

Prevalence and Pattern of Birth Defects in Saudi Arabia: A Systematic Review of Observational Studies

  • Ebtihal Elameen Eltyeb,
  • Majidah Hussain Asiri Halawi,
  • Thekra Badr Mohammed Tashari,
  • Khaled Alharbi,
  • Ohoud Saad Alsayari,
  • Danah Abdullah Albarrak,
  • Raga Abdelkhalig Eltayeb,
  • Ali Ali Ahmed Al-Makramani and
  • Isameldin Elamin M. Medani

20 July 2023

Introduction: Birth defects are a significant concern since they can lead to permanent disability and death. This study comprehensively reviews the prevalence and patterns of birth defects in Saudi Arabia. Methods: A systematic analysis of the litera...

  • Article
  • Open Access
7 Citations
2,403 Views
12 Pages

Administration of Clinical COVID-19 Mouthwashing Protocol and Potential Modulation of Pediatric Oral Bacterial Prevalence of Selenomonas noxia: A Pilot Study

  • Praneeti Sodhi,
  • Yuxin Jiang,
  • Summer Lin,
  • Jackson Downey,
  • Chase Sorenson,
  • Melika Shayegh,
  • Victoria Sullivan,
  • Karl Kingsley and
  • Katherine M. Howard

11 July 2023

Dental office protocols to combat the SARS-CoV-2 (COVID-19) pandemic include mouth washing for an extended 60 s, thereby reducing detectable oral virus. However, it is unclear whether this protocol has any effects on the newly identified periodontal...

  • Case Report
  • Open Access
8 Citations
3,937 Views
11 Pages

Recently, motorized mobility devices (or power mobility devices (PMDs)) have been introduced for infants and toddlers who lack the means for self-mobility. Previous reports have primarily focused on PMDs for individuals with cerebral palsy. Few have...

(This article belongs to the Section Pediatric Psychology)
  • Case Report
  • Open Access
2 Citations
3,948 Views
7 Pages

Severe and Atypical Presentation of Takotsubo Cardiomyopathy in a Pediatric Patient after a Serious Crash Injury—Case Report and Literature Review

  • Christos Tsitsipanis,
  • Marianna Miliaraki,
  • Maria Michailou,
  • Elisavet Geromarkaki,
  • Anna-Maria Spanaki,
  • Vasilia Nyktari,
  • Andreas Yannopoulos,
  • Nikolaos Moustakis and
  • Stavroula Ilia

30 June 2023

Takotsubo cardiomyopathy is an uncommon clinical entity in children, resulting in severe but sometimes reversible systolic dysfunction of the left ventricle. This condition is triggered by multiple emotional or physical stressors, while neurogenic st...

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Pediatr. Rep. - ISSN 2036-7503