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Neurology International, Volume 17, Issue 2

2025 February - 17 articles

Cover Story: Migraine with aura involves cortical spreading depression, a wave of neuronal depolarization triggered by ion channel dysfunction, calcium surges, and excess glutamate. Despite its prevalence, MwA’s pathophysiology is incompletely understood. fMRI reveals visual cortex hyperactivation during auras and hypoactivity interictally, suggesting chronic excitability shifts. Genetic variants implicate calcium signaling, while advanced neuroimaging shows persistent network dysfunction. Distinct visual cortex activation patterns differentiate MwA from other headaches, suggesting diagnostic biomarker potential. View this paper
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Articles (17)

  • Editorial
  • Open Access
2 Citations
1,017 Views
5 Pages

Neurodegenerative dementia, a collective term for a range of disorders characterized by progressive cognitive and functional decline, is an urgent challenge in global healthcare [...]

(This article belongs to the Topic Translational Advances in Neurodegenerative Dementias)
  • Brief Report
  • Open Access
2 Citations
2,200 Views
9 Pages

Introduction: Serum metabolome changes after acute ischemic stroke (AIS), but the significance of this is poorly understood. We evaluated whether this change is associated with AIS outcomes in patients with large vessel occlusion (LVO). To improve va...

(This article belongs to the Collection Biomarkers in Stroke Prognosis)
  • Article
  • Open Access
4 Citations
3,973 Views
10 Pages

Etiology and Mortality of Nonconvulsive Status Epilepticus

  • Firdevs Ezgi Uçan Tokuç,
  • Emine Görgülü,
  • Fatma Genç,
  • Meltem Korucuk and ,
  • Abidin Erdal and
  • Yasemin Biçer Gömceli
  • + 1 author+ 0 author

Objectives: Nonconvulsive status epilepticus (NCSE) is a disease with a high mortality rate and a very diverse etiology. The disease prognosis is related to the etiology. We aimed to investigate the etiology, mortality rates, and factors affecting mo...

  • Case Report
  • Open Access
1,977 Views
8 Pages

Background: Metachromatic leukodystrophy (MLD) is a rare autosomal recessive disorder that causes demyelination of both the central (CNS) and peripheral nervous systems (PNS). Objective: This study aims to report a unique MLD case presenting with cra...

  • Article
  • Open Access
4 Citations
2,526 Views
11 Pages

Background/Objectives: Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) are severe forms of stroke with high morbidity and mortality rates. HMG-CoA reductase inhibitors, commonly referred to as statins, known for their lipid-lowering...

  • Review
  • Open Access
47 Citations
13,931 Views
33 Pages

Alzheimer’s and Parkinson’s are the most common neurodegenerative diseases (NDDs). The development of aberrant protein aggregates and the progressive and permanent loss of neurons are the major characteristic features of these disorders....

(This article belongs to the Collection Advances in Neurodegenerative Diseases)
  • Article
  • Open Access
3,482 Views
12 Pages

Cardiac CT in Large Vessel Occlusion Stroke for the Evaluation of Non-Thrombotic and Non-Atrial-Fibrillation-Related Embolic Causes

  • Karim Mostafa,
  • Cosima Wünsche,
  • Sarah Krutmann,
  • Carmen Wolf and ,
  • Schekeb Aludin,
  • Naomi Larsen,
  • Alexander Seiler,
  • Domagoj Schunk,
  • Olav Jansen and
  • Patrick Langguth
  • + 6 authors+ 1 author

Background: The purpose of this study is the evaluation of imaging findings of acute-phase cardiac CT (cCT) in stroke patients with large vessel occlusion (LVO) to identify potential cardioembolic sources (CES) in patients without intracardiac thromb...

  • Case Report
  • Open Access
3,673 Views
7 Pages

A Rare Case of Bickerstaff Encephalitis in Childhood: A Case Report

  • Luca Gregorio Giaccari,
  • Donatella Mastria,
  • Rosella Barbieri,
  • Rossella De Maglio and ,
  • Francesca Madaro,
  • Gianfranco Paiano,
  • Luciana Mascia,
  • Maria Caterina Pace,
  • Giuseppe Pulito and
  • Pasquale Sansone
  • + 5 authors+ 0 author

Background: Bickerstaff brainstem encephalitis (BBE) is a rare autoimmune disease and approximately 74 cases have been reported in the literature, mostly in childhood. Methods: We reported this case report according to the CARE guidelines. Results: A...

  • Review
  • Open Access
6 Citations
5,446 Views
21 Pages

The Potential Role of Adipose-Derived Stem Cells in Regeneration of Peripheral Nerves

  • Sunil P. Mohan,
  • Sivan P. Priya,
  • Nada Tawfig,
  • Vivek Padmanabhan and ,
  • Rasha Babiker,
  • Arunkumar Palaniappan,
  • Srinivasan Prabhu,
  • Nallan CSK Chaitanya,
  • Muhammed Mustahsen Rahman and
  • Md Sofiqul Islam
  • + 5 authors+ 0 author

Peripheral nerve injuries are common complications in surgical and dental practices, often resulting in functional deficiencies and reduced quality of life. Current treatment choices, such as autografts, have limitations, including donor site morbidi...

(This article belongs to the Section Movement Disorders and Neurodegenerative Diseases)
  • Case Report
  • Open Access
1 Citations
2,492 Views
8 Pages

Severe Headache and Deterioration of Vision in Left Eye in a Chronic Hemodialysis Patient Revealing a Brown Tumor of Sphenoid Sinus

  • Hicham Esselmani,
  • Abdelmohcine Aimrane,
  • Hicham Chatoui,
  • Omar El Hiba and ,
  • Mustapha Najimi and
  • Mohamed Merzouki
  • + 1 author+ 0 author

Background/Objectives: Brown tumors are rare bone lesions associated with hyperparathyroidism, particularly secondary hyperparathyroidism (SHPT), in chronic renal failure. While brown tumors commonly affect bones rich in marrow, the involvement of th...

  • Article
  • Open Access
5 Citations
2,727 Views
11 Pages

Neurophysiological Markers of Adaptation and Compensation Following Lower Limb Amputation: An Analysis of EEG Oscillations and Clinical Predictors from the DEFINE Cohort Study

  • Guilherme J. M. Lacerda,
  • Valton Costa,
  • Lucas Camargo,
  • Linamara R. Battistella and ,
  • Marta Imamura and
  • Felipe Fregni
  • + 1 author+ 0 author

Background: Neuroplasticity, involving cortical and subcortical reorganization, plays a critical role in the adaptation and compensation process post-amputation. However, underlying neurophysiological changes remain unclear, particularly in brain osc...

  • Review
  • Open Access
3 Citations
5,235 Views
22 Pages

The Interplay Between Sleep Apnea and Postpartum Depression

  • Antonino Maniaci,
  • Luigi La Via,
  • Mario Lentini,
  • Basilio Pecorino and ,
  • Benito Chiofalo,
  • Giuseppe Scibilia,
  • Salvatore Lavalle,
  • Antonina Luca and
  • Paolo Scollo
  • + 4 authors+ 0 author

The complicated association between sleep apnea and postpartum depression (PPD), two diseases that can have a major influence on a mother’s health and well-being, is examined in this thorough review. An increasing number of people are realizing...

  • Review
  • Open Access
7 Citations
4,895 Views
16 Pages

Clonal hematopoiesis of indeterminate potential (CHIP) is increasingly recognized as a significant contributor to ischemic stroke and other cardiovascular diseases due to its association with somatic mutations in hematopoietic cells. These mutations,...

(This article belongs to the Special Issue Treatment Strategy and Mechanism of Acute Ischemic Stroke)
  • Article
  • Open Access
3 Citations
11,092 Views
11 Pages

Background: This study examined the impact of age-adjusted cerebrospinal fluid (CSF) protein levels on clinical characteristics, disease severity, and outcomes in Guillain–Barré Syndrome (GBS) patients. Methods: This retrospective study...

  • Systematic Review
  • Open Access
11 Citations
13,825 Views
16 Pages

Background: Peripheral facial paralysis (PFP) affects the facial nerve, the seventh cranial nerve. It has an incidence rate of 20–30 cases per 100,000 habitants. The diagnosis is clinical, though imaging tests may be required in some cases. The...

  • Case Report
  • Open Access
2 Citations
3,592 Views
16 Pages

Pituitary Spindle Cell Oncocytoma: More than a Grade 1 Tumor?

  • Jonathan Hammond,
  • Zacharie Gagne,
  • Bojana Mitrovic and
  • Stefano M. Priola

Background/Objectives: Spindle cell oncocytomas (SCOs) of the pituitary gland are rare tumors often misdiagnosed for nonfunctioning pituitary macroadenomas. Although classified as grade 1, they are often challenging in terms of diagnosis and treatmen...

  • Review
  • Open Access
8 Citations
7,673 Views
18 Pages

fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura

  • Damian Pikor,
  • Natalia Banaszek-Hurla,
  • Alicja Drelichowska,
  • Mikołaj Hurla and ,
  • Jolanta Dorszewska,
  • Tomasz Wolak and
  • Wojciech Kozubski
  • + 2 authors+ 0 author

Migraine with aura (MwA) is a common and severely disabling neurological disorder, characterised by transient yet recurrent visual disturbances, including scintillating scotomas, flickering photopsias, and complex geometric patterns. These episodic v...

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Neurol. Int. - ISSN 2035-8377