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The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

Touro College of Osteopathic Medicine, 60 Prospect Ave, Middletown, NY 10940, USA
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Academic Editor: Jeffrey A. Towbin
Cardiogenetics 2022, 12(1), 49-62; https://doi.org/10.3390/cardiogenetics12010005
Received: 13 October 2021 / Revised: 16 January 2022 / Accepted: 26 January 2022 / Published: 2 February 2022
(This article belongs to the Special Issue Cardiogenetics: Feature Papers 2021)
Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure. Platelet-activating factor (PAF) is a proinflammatory mediator synthesized from a subclass of phosphatidylcholines that increases platelet activation, leukocyte adhesion, infiltration of macrophages, and intracellular lipid accumulation, thereby contributing to atherosclerosis. Magnesium, a key micronutrient and free radical scavenger, is a water-soluble mineral that regulates peripheral vasodilation and calcium, phosphate, and hydroxyapatite homeostasis. Magnesium’s antihypertensive ability stems from its role as a natural calcium antagonist and promoter of vasodilatory mediators, such as nitric oxide. Platelet-activating factor and magnesium share an inverse relationship, and elevated magnesium levels have been shown to have protective effects against plaque formation as well as antihypertensive and antiarrhythmic effects, all of which allow for healthier aging. The purpose of this literature review is to investigate the role of platelet-activating factor and magnesium in the pathophysiology of hypertension, atherosclerosis, cardiovascular disease, stroke, and aging. Since the pathophysiology of the platelet-activating factor biomolecule is underexplored, further research studies are warranted in order to navigate the putative signaling pathways involved in the cardioprotective effects of dietary magnesium as a natural anti-PAF agent. View Full-Text
Keywords: hypertension; atherosclerosis; platelet-activating factor; magnesium hypertension; atherosclerosis; platelet-activating factor; magnesium
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MDPI and ACS Style

Shah, N.; Sethi, R.; Shah, S.; Jafri, K.; Duran, J.; Chang, Y.; Soni, C.; Wollocko, H. The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging. Cardiogenetics 2022, 12, 49-62. https://doi.org/10.3390/cardiogenetics12010005

AMA Style

Shah N, Sethi R, Shah S, Jafri K, Duran J, Chang Y, Soni C, Wollocko H. The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging. Cardiogenetics. 2022; 12(1):49-62. https://doi.org/10.3390/cardiogenetics12010005

Chicago/Turabian Style

Shah, Nilank, Roshni Sethi, Sachin Shah, Komail Jafri, Jonah Duran, Yong Chang, Chirag Soni, and Hanna Wollocko. 2022. "The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging" Cardiogenetics 12, no. 1: 49-62. https://doi.org/10.3390/cardiogenetics12010005

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