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Case Report

Genetic Diagnosis in Sudden Cardiac Death: The Crucial Role of Multidisciplinary Care

1
Department of Clinical Genetics, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
2
Department of Pulmonology, Amsterdam University Medical Centers, Vrije Universiteit (VU) Amsterdam, 1007 MB Amsterdam, The Netherlands
3
Independent Researcher, 2012 LG Haarlem, The Netherlands
4
Heart Centre, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
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Department of Pathology and Cardiac Surgery, ACS, Amsterdam University Medical Centers, Vrije Universiteit (VU) Amsterdam, 1007 MB Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editors: Tiina Heliö, Juha W. Koskenvuo and Katriina Aalto-Setälä
Cardiogenetics 2021, 11(2), 68-72; https://doi.org/10.3390/cardiogenetics11020008
Received: 1 April 2021 / Revised: 4 May 2021 / Accepted: 10 May 2021 / Published: 13 May 2021
(This article belongs to the Special Issue Genetic Diagnostics in Inherited Cardiomyopathies)
Sudden death, especially at a young age, may be caused by an underlying genetic cause. Hereditary conditions with an increased risk of sudden death at a young age include cardiomyopathies, arrhythmia syndromes, and hereditary thoracic aortic aneurysms and dissections. The identification of a genetic cause allows for genetic testing and cardiological surveillance in at-risk relatives. Three sudden death cases from our hospital illustrate the value of autopsy, genetic, and cardiological screening in relatives following a sudden death. On autopsy, histology consistent with hereditary cardiomyopathy is a reason for the referral of relatives. In addition, in the absence of an identifiable cause of death by autopsy in young sudden death patients, arrhythmia syndrome should be considered as a potential genetic cause. View Full-Text
Keywords: sudden death; autopsy; DNA diagnostics sudden death; autopsy; DNA diagnostics
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MDPI and ACS Style

van der Crabben, S.N.; Komdeur, F.L.; Nossent, E.J.; Deprez, R.H.L.; Broekhuizen, E.A.; van der Werf, C.; Vermeer, A.M.C.; Niessen, H.W.M.; Houweling, A.C. Genetic Diagnosis in Sudden Cardiac Death: The Crucial Role of Multidisciplinary Care. Cardiogenetics 2021, 11, 68-72. https://doi.org/10.3390/cardiogenetics11020008

AMA Style

van der Crabben SN, Komdeur FL, Nossent EJ, Deprez RHL, Broekhuizen EA, van der Werf C, Vermeer AMC, Niessen HWM, Houweling AC. Genetic Diagnosis in Sudden Cardiac Death: The Crucial Role of Multidisciplinary Care. Cardiogenetics. 2021; 11(2):68-72. https://doi.org/10.3390/cardiogenetics11020008

Chicago/Turabian Style

van der Crabben, S. N.; Komdeur, F. L.; Nossent, E. J.; Deprez, R. H.L.; Broekhuizen, E. A.; van der Werf, C.; Vermeer, A. M.C.; Niessen, H. W.M.; Houweling, A. C. 2021. "Genetic Diagnosis in Sudden Cardiac Death: The Crucial Role of Multidisciplinary Care" Cardiogenetics 11, no. 2: 68-72. https://doi.org/10.3390/cardiogenetics11020008

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