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Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities
Article

Usefulness of Artificial Membrane, Strat-M®, in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions

1
Department of Pharmacy, University of San Carlos, Cebu City 6000, Philippines
2
Graduate School of Pharmaceutical Sciences, Josai University, Saitama 350-0295, Japan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 173; https://doi.org/10.3390/pharmaceutics12020173
Received: 31 January 2020 / Revised: 13 February 2020 / Accepted: 18 February 2020 / Published: 19 February 2020
(This article belongs to the Special Issue Transdermal Drug Delivery Systems)
The ban on the use of animals in testing cosmetic products has led to the development of animal-free in vitro methods. Strat-M® is an artificial membrane engineered to mimic human skin and is recommended as a replacement for skin. However, its usefulness in the assessment of the permeation of cosmetics in in-use conditions remains unverified. No data have been published on its comparative performance with the membrane of choice, porcine skin. The comparative permeability characteristics of Strat-M® and porcine skin were investigated using Franz diffusion cells. Caffeine (CF) and rhododendrol (RD) in complex vehicles with varying concentrations of polyols were applied as finite and infinite doses. Good rank orders of permeation from finite dose experiments were observed for RD. High correlations were observed in RD permeation between Strat-M® and porcine skin under finite and infinite dose conditions, whereas only finite dose conditions for CF were associated with good correlations. Permeation from formulations with high polyol content and residual formulations was enhanced due to the disruption of the integrity of the Strat-M® barrier. The usefulness of Strat-M® in the assessment of dermal permeation may be limited to finite dose conditions and not applicable to infinite dose conditions or formulations applied in layers. View Full-Text
Keywords: Strat-M®; alternative membrane; in vitro skin permeation; complex vehicles; cosmetics Strat-M®; alternative membrane; in vitro skin permeation; complex vehicles; cosmetics
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MDPI and ACS Style

Arce, F.J.; Asano, N.; See, G.L.; Itakura, S.; Todo, H.; Sugibayashi, K. Usefulness of Artificial Membrane, Strat-M®, in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions. Pharmaceutics 2020, 12, 173. https://doi.org/10.3390/pharmaceutics12020173

AMA Style

Arce FJ, Asano N, See GL, Itakura S, Todo H, Sugibayashi K. Usefulness of Artificial Membrane, Strat-M®, in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions. Pharmaceutics. 2020; 12(2):173. https://doi.org/10.3390/pharmaceutics12020173

Chicago/Turabian Style

Arce, Florencio J.; Asano, Narumi; See, Gerard L.; Itakura, Shoko; Todo, Hiroaki; Sugibayashi, Kenji. 2020. "Usefulness of Artificial Membrane, Strat-M®, in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions" Pharmaceutics 12, no. 2: 173. https://doi.org/10.3390/pharmaceutics12020173

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