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Article

A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog

1
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea
2
College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Seoul 21983, Korea
3
College of Pharmacy, Chung-ang University, Seoul 06974, Korea
4
CK Biotechnology Inc., Rm 417, Engineering Research Park, 50 Yonsei Ro, Seodaemun-Gu, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 175; https://doi.org/10.3390/pharmaceutics12020175
Received: 9 January 2020 / Revised: 11 February 2020 / Accepted: 12 February 2020 / Published: 19 February 2020
(This article belongs to the Special Issue Transdermal Drug Delivery Systems)
Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia. The therapeutic effects of indirubin analogs have been underestimated due to its poor water solubility and low bioavailability. To improve the solubility and bioavailability of indirubin analogs, we prepared a mixed micellar formulation with Kolliphor® EL and Tween 80 as surfactants, and PEG 400 as a co-surfactant, followed by complexation with (2-hydroxyproply)-β-cyclodextrin at appropriate ratios. Overall, improving the solubility and skin penetration of indirubin analogs can increase clinical efficacy and provide maximum flux through the skin. View Full-Text
Keywords: mixed micellar formulation; transdermal drug delivery; solvent-free delivery system; lipophilic drugs mixed micellar formulation; transdermal drug delivery; solvent-free delivery system; lipophilic drugs
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MDPI and ACS Style

Seo, S.H.; Kim, E.; Joo, Y.; Lee, J.; Oh, K.T.; Hwang, S.-J.; Choi, K.-Y. A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog. Pharmaceutics 2020, 12, 175. https://doi.org/10.3390/pharmaceutics12020175

AMA Style

Seo SH, Kim E, Joo Y, Lee J, Oh KT, Hwang S-J, Choi K-Y. A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog. Pharmaceutics. 2020; 12(2):175. https://doi.org/10.3390/pharmaceutics12020175

Chicago/Turabian Style

Seo, Seol H., Eunhwan Kim, Yechan Joo, Juseung Lee, Kyung T. Oh, Sung-Joo Hwang, and Kang-Yell Choi. 2020. "A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog" Pharmaceutics 12, no. 2: 175. https://doi.org/10.3390/pharmaceutics12020175

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