Next Article in Journal
Usefulness of Artificial Membrane, Strat-M®, in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions
Previous Article in Journal
Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers
Open AccessArticle

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

1
Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK
2
FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK
3
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 172; https://doi.org/10.3390/pharmaceutics12020172
Received: 21 December 2019 / Revised: 27 January 2020 / Accepted: 11 February 2020 / Published: 19 February 2020
Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment. View Full-Text
Keywords: three-dimensional printing; 3D printed drug products; orally disintegrating tablets; personalised medicines; personalized pharmaceuticals; blindness; visual deprivation; touch-reading compliance; tactile patterns; sight loss three-dimensional printing; 3D printed drug products; orally disintegrating tablets; personalised medicines; personalized pharmaceuticals; blindness; visual deprivation; touch-reading compliance; tactile patterns; sight loss
Show Figures

Graphical abstract

MDPI and ACS Style

Awad, A.; Yao, A.; Trenfield, S.J.; Goyanes, A.; Gaisford, S.; Basit, A.W. 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients. Pharmaceutics 2020, 12, 172.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop