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Viruses 2016, 8(6), 174;

Phleboviruses and the Type I Interferon Response

Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen 35392, Germany
Author to whom correspondence should be addressed.
Academic Editors: Jane Tao and Pierre-Yves Lozach
Received: 8 May 2016 / Revised: 15 June 2016 / Accepted: 20 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Recent Progress in Bunyavirus Research)
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The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly fever Sicilian virus (SFSV), Toscana virus (TOSV), Punta Toro virus (PTV), and the two new members severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV). The nonstructural protein NSs is well established as the main phleboviral virulence factor in the mammalian host. NSs acts as antagonist of the antiviral type I interferon (IFN) system. Recent progress in the elucidation of the molecular functions of a growing list of NSs proteins highlights the astonishing variety of strategies employed by phleboviruses to evade the IFN system. View Full-Text
Keywords: phlebovirus; NSs protein; interferon; RIG-I; PKR phlebovirus; NSs protein; interferon; RIG-I; PKR

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Wuerth, J.D.; Weber, F. Phleboviruses and the Type I Interferon Response. Viruses 2016, 8, 174.

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