Alphaherpesvirus Subversion of Stress-Induced Translational Arrest

Finnen, Renée L.; Banfield, Bruce W.

doi:10.3390/v8030081

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Alphaherpesvirus Subversion of Stress-Induced Translational Arrest

by

Renée L. Finnen

and

Bruce W. Banfield

^*

Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada

^*

Author to whom correspondence should be addressed.

Viruses 2016, 8(3), 81; https://doi.org/10.3390/v8030081

Submission received: 21 January 2016 / Revised: 1 March 2016 / Accepted: 2 March 2016 / Published: 15 March 2016

(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)

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Abstract

In this article, we provide an overview of translational arrest in eukaryotic cells in response to stress and the tactics used specifically by alphaherpesviruses to overcome translational arrest. One consequence of translational arrest is the formation of cytoplasmic compartments called stress granules (SGs). Many viruses target SGs for disruption and/or modification, including the alphaherpesvirus herpes simplex virus type 2 (HSV-2). Recently, it was discovered that HSV-2 disrupts SG formation early after infection via virion host shutoff protein (vhs), an endoribonuclease that is packaged within the HSV-2 virion. We review this discovery and discuss the insights it has provided into SG biology as well as its potential significance in HSV-2 infection. A model for vhs-mediated disruption of SG formation is presented.

Keywords: alphaherpesvirus; translational arrest; stress granules

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MDPI and ACS Style

Finnen, R.L.; Banfield, B.W. Alphaherpesvirus Subversion of Stress-Induced Translational Arrest. Viruses 2016, 8, 81. https://doi.org/10.3390/v8030081

AMA Style

Finnen RL, Banfield BW. Alphaherpesvirus Subversion of Stress-Induced Translational Arrest. Viruses. 2016; 8(3):81. https://doi.org/10.3390/v8030081

Chicago/Turabian Style

Finnen, Renée L., and Bruce W. Banfield. 2016. "Alphaherpesvirus Subversion of Stress-Induced Translational Arrest" Viruses 8, no. 3: 81. https://doi.org/10.3390/v8030081

APA Style

Finnen, R. L., & Banfield, B. W. (2016). Alphaherpesvirus Subversion of Stress-Induced Translational Arrest. Viruses, 8(3), 81. https://doi.org/10.3390/v8030081

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Alphaherpesvirus Subversion of Stress-Induced Translational Arrest

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