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Communication

Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes

1
Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada
2
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada
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Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 0G4, Canada
4
Department of Biochemistry, Microbiology and Immunology, and Center for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON K1H 8M5, Canada
5
Laboratoire de Santé Publique du Québec, Institut Nationale de Santé Publique du Québec, Sainte-Anne-de-Bellevue, QC H9X 3R5, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Kenzo Tokunaga and Jérôme Estaquier
Viruses 2022, 14(1), 144; https://doi.org/10.3390/v14010144
Received: 13 December 2021 / Revised: 7 January 2022 / Accepted: 10 January 2022 / Published: 14 January 2022
(This article belongs to the Special Issue Basic Sciences for the Conquest of COVID-19)
The rapid emergence of SARS-CoV-2 variants is fueling the recent waves of the COVID-19 pandemic. Here, we assessed ACE2 binding and antigenicity of Mu (B.1.621) and A.2.5 Spikes. Both these variants carry some mutations shared by other emerging variants. Some of the pivotal mutations such as N501Y and E484K in the receptor-binding domain (RBD) detected in B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma) are now present within the Mu variant. Similarly, the L452R mutation of B.1.617.2 (Delta) variant is present in A.2.5. In this study, we observed that these Spike variants bound better to the ACE2 receptor in a temperature-dependent manner. Pseudoviral particles bearing the Spike of Mu were similarly neutralized by plasma from vaccinated individuals than those carrying the Beta (B.1.351) and Delta (B.1.617.2) Spikes. Altogether, our results indicate the importance of measuring critical parameters such as ACE2 interaction, plasma recognition and neutralization ability of each emerging variant. View Full-Text
Keywords: coronavirus; COVID-19; SARS-CoV-2; spike glycoproteins; RBD; ACE2; temperature; variants of concern; variants of interest; variants under monitoring; mRNA vaccines coronavirus; COVID-19; SARS-CoV-2; spike glycoproteins; RBD; ACE2; temperature; variants of concern; variants of interest; variants under monitoring; mRNA vaccines
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MDPI and ACS Style

Chatterjee, D.; Tauzin, A.; Laumaea, A.; Gong, S.Y.; Bo, Y.; Guilbault, A.; Goyette, G.; Bourassa, C.; Gendron-Lepage, G.; Medjahed, H.; Richard, J.; Moreira, S.; Côté, M.; Finzi, A. Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes. Viruses 2022, 14, 144. https://doi.org/10.3390/v14010144

AMA Style

Chatterjee D, Tauzin A, Laumaea A, Gong SY, Bo Y, Guilbault A, Goyette G, Bourassa C, Gendron-Lepage G, Medjahed H, Richard J, Moreira S, Côté M, Finzi A. Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes. Viruses. 2022; 14(1):144. https://doi.org/10.3390/v14010144

Chicago/Turabian Style

Chatterjee, Debashree, Alexandra Tauzin, Annemarie Laumaea, Shang Y. Gong, Yuxia Bo, Aurélie Guilbault, Guillaume Goyette, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Jonathan Richard, Sandrine Moreira, Marceline Côté, and Andrés Finzi. 2022. "Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes" Viruses 14, no. 1: 144. https://doi.org/10.3390/v14010144

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