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Volume 13
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Review

Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity

by
Hsuan-Yuan Wang
1,2,
Sarah M. Valencia
2,
Susanne P. Pfeifer
3,
Jeffrey D. Jensen
3,
Timothy F. Kowalik
4 and
Sallie R. Permar
1,*
1
Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA
2
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
3
Center for Evolution & Medicine, School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA
4
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
*
Author to whom correspondence should be addressed.
Viruses 2021, 13(6), 1106; https://doi.org/10.3390/v13061106
Submission received: 16 April 2021 / Revised: 4 June 2021 / Accepted: 7 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Cytomegalovirus Immunity 2021)
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Abstract

Human cytomegalovirus (HCMV), one of the most prevalent viruses across the globe, is a common cause of morbidity and mortality for immunocompromised individuals. Recent clinical observations have demonstrated that mixed strain infections are common and may lead to more severe disease progression. This clinical observation illustrates the complexity of the HCMV genome and emphasizes the importance of taking a population-level view of genotypic evolution. Here we review frequently sampled polymorphisms in the glycoproteins of HCMV, comparing the variable regions, and summarizing their corresponding geographic distributions observed to date. The related strain-specific immunity, including neutralization activity and antigen-specific cellular immunity, is also discussed. Given that these glycoproteins are common targets for vaccine design and anti-viral therapies, this observed genetic variation represents an important resource for future efforts to combat HCMV infections.
Keywords: human cytomegalovirus; glycoprotein; polymorphism; genotype; strain-specific immunity human cytomegalovirus; glycoprotein; polymorphism; genotype; strain-specific immunity

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MDPI and ACS Style

Wang, H.-Y.; Valencia, S.M.; Pfeifer, S.P.; Jensen, J.D.; Kowalik, T.F.; Permar, S.R. Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity. Viruses 2021, 13, 1106. https://doi.org/10.3390/v13061106

AMA Style

Wang H-Y, Valencia SM, Pfeifer SP, Jensen JD, Kowalik TF, Permar SR. Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity. Viruses. 2021; 13(6):1106. https://doi.org/10.3390/v13061106

Chicago/Turabian Style

Wang, Hsuan-Yuan, Sarah M. Valencia, Susanne P. Pfeifer, Jeffrey D. Jensen, Timothy F. Kowalik, and Sallie R. Permar. 2021. "Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity" Viruses 13, no. 6: 1106. https://doi.org/10.3390/v13061106

APA Style

Wang, H.-Y., Valencia, S. M., Pfeifer, S. P., Jensen, J. D., Kowalik, T. F., & Permar, S. R. (2021). Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity. Viruses, 13(6), 1106. https://doi.org/10.3390/v13061106

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