Viruses, Volume 12, Issue 3 (March 2020) – 107 articles
Cover Story (view full-size image): The COVID-19 outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global threat. Vaccines are widely recognized as important for controlling and preventing this pandemic. This work identifies potential vaccine targets against SARS-CoV-2. These targets are found by exploiting the genetic similarity between SARS-CoV-2 and SARS-CoV (the virus causing the 2003 SARS outbreak), together with existing immunological studies of SARS-CoV. It is shown that about 20% of the known SARS-derived T cell and B cell epitopes have an identical genetic match in SARS-CoV-2, comprising no mutation in the SARS-CoV-2 sequences available at the time of the study. These epitopes are promising candidates for triggering an effective cross-reactive immune response against SARS-CoV-2. View this paper.
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