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Mast Cells and Natural Killer Cells—A Potentially Critical Interaction

1
Dalhousie Human Immunology and Inflammation Group, Dalhousie University, Halifax, NS B3H 4R2, Canada
2
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada
3
Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(6), 514; https://doi.org/10.3390/v11060514
Received: 26 April 2019 / Revised: 31 May 2019 / Accepted: 2 June 2019 / Published: 4 June 2019
(This article belongs to the Special Issue The Role of NK Cells in Antiviral Innate Immunity)
Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response including the killing of target cells without the need for priming. However, activated NK cells can show improved effector functions. Mast cells are also critical for early host defense against a variety of pathogens and are predominately located at mucosal surfaces and close to blood vessels. Our group has recently shown that virus-infected mast cells selectively recruit NK cells and positively modulate their functions through mechanisms dependent on soluble mediators, such as interferons. Here, we review the possible consequences of this interaction in both host defense and pathologies involving NK cell and mast cell activation. View Full-Text
Keywords: mast cells; NK cells; cytokines; CXCL8; interferons; cell recruitment; cellular activation; oncolytic virus mast cells; NK cells; cytokines; CXCL8; interferons; cell recruitment; cellular activation; oncolytic virus
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MDPI and ACS Style

Portales-Cervantes, L.; Dawod, B.; Marshall, J.S. Mast Cells and Natural Killer Cells—A Potentially Critical Interaction. Viruses 2019, 11, 514.

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