The Role of NK Cells in Antiviral Innate Immunity
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (31 March 2019) | Viewed by 48595
Special Issue Editors
Interests: We investigate how human natural killer cell immunogenetics program immune responsiveness to cancer and infectious diseases. We use bioinformatics, humanized in vivo models, cell-signal analysis, and highly-parametric flow cytometry to understand how genetic variation creates diversity in human immune potentials. Our interdisciplinary and collaborative work aims to translate research findings into precision therapies.
Interests: influenza A virus; Kaposi’s sarcoma-associated herpesvirus; viral oncogenes; mRNA turnover and translation; stress granules; p-bodies; autophagy; unfolded protein response; inflammation; host shutoff
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The early and ongoing control of viral infections requires robust host innate immune defences. Innate-like lymphocytes including natural killer (NK) cells are critical and early responders to virus infections and play lead roles in controlling chronic infections by herpes viruses, hepatitis viruses and HIV. Increasingly, subpopulations of NK cells and NK cell immunogenetics are understood to predict the outcomes of virus–host interactions and viral mechanisms to manipulate host innate defences are being uncovered. An increasing body of evidence is demonstrating that viruses have driven the evolution of NK cell function; reciprocally, innate immune defences pressure virus evolution for the increased virulence, latency or polarization of innate immune responses. The goal of this Special Issue of Viruses is to explore interactions between NK cells and viruses.
Primary research and review articles pertaining to virus interactions with NK and NK-related immune populations are invited. Topics of interest include, but are not limited to, the following:
- Co-evolution of virus and host defence factors,
- Viral mechanisms of immune evasion,
- Antiviral mechanisms of NK cells and ILC,
- Consequences of virus–host interactions, including immune senescence or viral latency,
- Viral pathogenesis by immune evasion or immunopathology,
- Interactions between viruses and NK-related immune populations including innate lymphoid cells (ILC), NKT and MAIT cells,
- Innate immune-based vaccination and anti-viral immunotherapy.
Dr. Jeanette Boudreau
Dr. Craig McCormick
Guest Editors
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Keywords
- natural killer cells
- virus
- NK cells
- innate immunity
- anti-viral response
- co-evolution
- host-defence
- innate lymphoid cells
- invariant T cells (NKT, MAIT, γδT cells)
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