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Manipulation of Epithelial Differentiation by HPV Oncoproteins

Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Viruses 2019, 11(4), 369;
Received: 18 March 2019 / Revised: 18 April 2019 / Accepted: 20 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Viruses Ten-Year Anniversary)
PDF [1031 KB, uploaded 22 April 2019]


Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhibit and/or delay epithelial differentiation and some of the mechanisms by which they do so are beginning to be defined. This review will outline the key features of the relationship between HPV infection and differentiation and will summarize the data indicating that papillomaviruses alter epithelial differentiation. It will describe what is known so far and will highlight open questions about the differentiation-inhibitory mechanisms employed by the papillomaviruses. View Full-Text
Keywords: virus; transformation; epithelial; differentiation; HPV virus; transformation; epithelial; differentiation; HPV

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White, E.A. Manipulation of Epithelial Differentiation by HPV Oncoproteins. Viruses 2019, 11, 369.

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