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Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses

Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80523-1692, USA
Author to whom correspondence should be addressed.
Viruses 2019, 11(3), 225;
Received: 31 January 2019 / Revised: 21 February 2019 / Accepted: 21 February 2019 / Published: 6 March 2019
(This article belongs to the Special Issue Viruses and Cellular Metabolism)
PDF [1864 KB, uploaded 6 March 2019]


The global burden of arboviral diseases and the limited success in controlling them calls for innovative methods to understand arbovirus infections. Metabolomics has been applied to detect alterations in host physiology during infection. This approach relies on mass spectrometry or nuclear magnetic resonance spectroscopy to evaluate how perturbations in biological systems alter metabolic pathways, allowing for differentiation of closely related conditions. Because viruses heavily depend on host resources and pathways, they present unique challenges for characterizing metabolic changes. Here, we review the literature on metabolomics of arboviruses and focus on the interpretation of identified molecular features. Metabolomics has revealed biomarkers that differentiate disease states and outcomes, and has shown similarities in metabolic alterations caused by different viruses (e.g., lipid metabolism). Researchers investigating such metabolomic alterations aim to better understand host–virus dynamics, identify diagnostically useful molecular features, discern perturbed pathways for therapeutics, and guide further biochemical research. This review focuses on lessons derived from metabolomics studies on samples from arbovirus-infected humans. View Full-Text
Keywords: arbovirus; metabolomics; metabolism; alphavirus; flavivirus; lipid arbovirus; metabolomics; metabolism; alphavirus; flavivirus; lipid

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Byers, N.M.; Fleshman, A.C.; Perera, R.; Molins, C.R. Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses. Viruses 2019, 11, 225.

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