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Volume 15
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10.3390/ma15093132
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Article

Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’

by
Makoto Sasaki
1,*,
Wei Xu
1,*,
Yuki Koga
2,
Yuki Okazawa
3,
Akira Wada
2,
Ichiro Shimizu
4 and
Takuro Niidome
1
1
Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan
2
Japan Medical Device Technology, Co., Ltd., Kumamoto 861-2202, Japan
3
Fuji Light Metal, Co., Ltd., Kumamoto 869-0192, Japan
4
Department of Mechanical Engineering, Okayama University of Science, Okayama 700-0005, Japan
*
Authors to whom correspondence should be addressed.
Materials 2022, 15(9), 3132; https://doi.org/10.3390/ma15093132
Submission received: 20 March 2022 / Revised: 18 April 2022 / Accepted: 25 April 2022 / Published: 26 April 2022
(This article belongs to the Special Issue Innovative Technologies and Materials for the Production of Mechanical, Thermal and Corrosion Wear-Resistant Surface Layers and Coatings)
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Abstract

Magnesium (Mg) alloy has attracted significant attention as a bioresorbable scaffold for use as a next-generation stent because of its mechanical properties and biocompatibility. However, Mg alloy quickly degrades in the physiological environment. In this study, we investigated whether applying a parylene C coating can improve the corrosion resistance of a Mg alloy stent, which is made of ‘Original ZM10’, free of aluminum and rare earth elements. The coating exhibited a smooth surface with no large cracks, even after balloon expansion of the stent, and improved the corrosion resistance of the stent in cell culture medium. In particular, the parylene C coating of a hydrofluoric acid-treated Mg alloy stent led to excellent corrosion resistance. In addition, the parylene C coating did not affect a polymer layer consisting of poly(ε-caprolactone) and poly(D,L-lactic acid) applied as an additional coating for the drug release to suppress restenosis. Parylene C is a promising surface coating for bioresorbable Mg alloy stents for clinical applications.
Keywords: corrosion resistance; magnesium alloy; bioresorbable stent; parylene C; surface coating corrosion resistance; magnesium alloy; bioresorbable stent; parylene C; surface coating

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MDPI and ACS Style

Sasaki, M.; Xu, W.; Koga, Y.; Okazawa, Y.; Wada, A.; Shimizu, I.; Niidome, T. Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’. Materials 2022, 15, 3132. https://doi.org/10.3390/ma15093132

AMA Style

Sasaki M, Xu W, Koga Y, Okazawa Y, Wada A, Shimizu I, Niidome T. Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’. Materials. 2022; 15(9):3132. https://doi.org/10.3390/ma15093132

Chicago/Turabian Style

Sasaki, Makoto, Wei Xu, Yuki Koga, Yuki Okazawa, Akira Wada, Ichiro Shimizu, and Takuro Niidome. 2022. "Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’" Materials 15, no. 9: 3132. https://doi.org/10.3390/ma15093132

APA Style

Sasaki, M., Xu, W., Koga, Y., Okazawa, Y., Wada, A., Shimizu, I., & Niidome, T. (2022). Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’. Materials, 15(9), 3132. https://doi.org/10.3390/ma15093132

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