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Materials 2019, 12(6), 865; https://doi.org/10.3390/ma12060865

Effect by Diamond Surface Modification on Biomolecular Adhesion

Department of Chemistry—Ångström Laboratory, Uppsala University, BOX 538, 75121 Uppsala, Sweden
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Received: 16 January 2019 / Revised: 6 March 2019 / Accepted: 11 March 2019 / Published: 15 March 2019
(This article belongs to the Special Issue Nanodiamond Particles: Properties and Applications)
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Abstract

Diamond, as material, show very attractive properties. They include superior electronic properties (when doped), chemical inertness, controllable surface termination, and biocompatibility. It is thus clear that surface termination is very important for those applications where the implant material is based on diamond. The present theoretical work has focused on the effect of diamond surface termination, in combination with type of surface plane, on the adhesion of important biomolecules for vascularization and bone regeneration. These biomolecules include Arginine-Glycine-Aspartic acid (RGD), Chitosan, Heparin, Bone Morphogenetic Protein 2 (BMP2), Angiopoietin 1 (AGP1), Fibronectin and Vascular Endothelial Growth Factor (VEGF). The various surface planes are diamond diamond (100)-2x1 and (111). The theoretical results show that the non-covalent binding of these biomolecules is in proportion with their molecular weights. Moreover, three groups of biomolecules were observed for both types of surface planes. The most strongly binding biomolecule was the BMP2 molecule. The smaller polypeptides (RGD, Chitosan and Heparin) formed a less strongly binding group. Finally, the biomolecules VEGF, Fibronectin and Angiopoietin showed bond strengths numerically in between the other two groups (thereby forming a third group). Moreover, the (111) surface was generally observed to display a stronger bonding of the biomolecules, as compared with the (100)-2x1 surface. View Full-Text
Keywords: diamond; theory; biomolecules diamond; theory; biomolecules
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tian, Y.; Larsson, K. Effect by Diamond Surface Modification on Biomolecular Adhesion. Materials 2019, 12, 865.

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