The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Description of Variables
2.3. Statistical Methods
3. Results
3.1. Sociodemographic and Clinical Characteristics
3.2. Correlations across Variables
3.3. The Mediating Role of Exercise in the Relationship between Depression and Fatigue
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
(1) | Hospital Universitario de Canarias, Tenerife |
(2) | Hospital Universitario La Paz, Madrid |
(3) | Hospital Universitario Central de Asturias, Oviedo |
(4) | Complejo Hospitalario Universitario de Ourense |
(5) | Hospital Universitario Infanta Leonor, Madrid |
(6) | Consorcio Hospital General Universitario de Valencia, Valencia |
(7) | Hospital General Virgen de la Luz, Cuenca |
(8) | Hospital Provincial de Castellón, Castellón |
(9) | Hospital General Universitario de Elche, Elche |
(10) | Hospital Universitario Clínico San Carlos, Madrid |
(11) | Hospital San Pedro de Alcántara, Cáceres |
(12) | Hospital Universitario Morales Meseguer, Murcia |
(13) | Hospital Quironsalud Sagrado Corazón de Sevilla, Sevilla |
(14) | Hospital General Universitario Santa Lucia, Cartagena |
(15) | Hospital General de Ciudad Real, Ciudad Real |
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Characteristics | N (%) | Depression (Mean ± SD) | Exercise (Mean ± SD) | Fatigue (Mean ± SD) |
---|---|---|---|---|
Sex | ||||
Male | 329 (53.4) | 59.7 ± 5.6 | 56.3 ± 29.4 | 23.8 ± 6.7 |
Female | 287 (46.6) | 62.7 ± 6.9 | 53.3 ± 30.1 | 24.7 ± 6.6 |
p value | 0.001 | 0.204 | 0.098 | |
Age | 35.486 | 1.617 | 2.753 | |
≤60 years | 186 (30.2) | 62.4 ± 6.6 | 57.7 ± 30.6 | 24.2 ± 6.3 |
61–70 years | 217 (35.2) | 61.0 ± 5.9 | 57.8 ± 27.6 | 24.4 ± 6.9 |
>70 years | 213 (34.6) | 60.1 ± 6.5 | 49.6 ± 30.4 | 24.0 ± 6.8 |
p value | 0.003 | 0.006 | 0.774 | |
Marital Status | 6.009 | 5.194 | 0.257 | |
Married/partnered | 419 (68.0) | 60.7 ± 6.1 | 56.1 ± 29.2 | 24.4 ± 6.4 |
Not partnered | 197 (32.0) | 61.9 ± 6.9 | 52.5 ± 30.6 | 23.9 ± 7.2 |
p value | 0.034 | 0.175 | 0.395 | |
Educational level | 4.535 | 1.848 | 0.724 | |
Primary | 272 (44.2) | 61.1 ± 6.6 | 46.4 ± 29.8 | 24.4 ± 7.7 |
High school or higher | 344 (55.8) | 61.2 ± 6.2 | 61.6 ± 27.9 | 24.0 ± 5.8 |
p value | 0.718 | 0.001 | 0.442 | |
Employment | 0.130 | 42.783 | 0.591 | |
Unemployed | 444 (72.1) | 61.2 ± 6.4 | 53.3 ± 29.9 | 23.8 ± 6.5 |
Employed | 172 (27.9) | 61.1 ± 6.5 | 59.1 ± 28.8 | 25.3 ± 6.9 |
p value | 0.822 | 0.031 | 0.015 |
Characteristics | N (%) | Depression (Mean ± SD) | Exercise (Mean ± SD) | Fatigue (Mean ± SD) |
---|---|---|---|---|
Tumor site | ||||
Bronchopulmonary | 197 (32.0) | 61.1 ± 6.5 | 53.9 ± 28.2 | 23.9 ± 6.5 |
Colorectum | 100 (16.2) | 60.9 ± 6.5 | 54.8 ± 30.0 | 24.5 ± 6.9 |
Breast | 68 (11.0) | 60.4 ± 5.8 | 55.2 ± 29.2 | 23.4 ± 5.7 |
Pancreas | 60 (9.7) | 61.4 ± 6.4 | 51.6 ± 30.3 | 23.7 ± 6.8 |
Stomach | 30 (4.9) | 61.4 ± 7.3 | 55.1 ± 33.9 | 24.9 ± 7.1 |
Others | 161 (26.1) | 61.5 ± 6.4 | 57.2 ± 29.5 | 24.2 ± 6.7 |
p value | 0.884 | 0.856 | 0.640 | |
Histology | ||||
Adenocarcinoma | 429 (69.6) | 60.9 ± 6.3 | 56.5 ± 29.2 | 24.4 ± 6.8 |
Others | 187 (30.4) | 61.7 ± 6.6 | 51.3 ± 30.7 | 24.5 ± 6.4 |
p value | 0.052 | 0.138 | 0.455 | |
Stage | ||||
Locally Advanced | 118 (19.2) | 61.2 ± 6.9 | 50.0 ± 31.7 | 25.3 ± 7.1 |
Metastatic (IV) | 498 (80.8) | 61.1 ± 6.3 | 52.5 ± 30.6 | 24.0 ± 6.5 |
p value | 0.870 | 0.058 | 0.059 | |
Type of treatment | ||||
Only CT | 294 (47.7) | 61.2 ± 6.5 | 50.4 ± 30.7 | 24.9 ± 7.1 |
CT with other | 237 (38.5) | 61.0 ± 6.2 | 58.4 ± 28.1 | 23.6 ± 6.1 |
Immunotherapy | 43 (7.0) | 60.6 ± 6.4 | 56.8 ± 31.8 | 23.6 ± 7.0 |
Targeted therapies | 42 (6.8) | 62.1 ± 7.0 | 58.0 ± 25.4 | 23.8 ± 6.7 |
p value | 0.386 | 0.143 | 0.081 | |
ECOG-PS | ||||
0 | 274 (44.5) | 59.9 ± 6.1 | 65.4 ± 26.3 | 23.3 ± 6.3 |
1 or more | 342 (55.5) | 62.1 ± 6.5 | 46.4 ± 29.6 | 25.0 ± 6.9 |
p value | 0.001 | 0.001 | 0.002 |
Mean | SD | Depression | Exercise | |
---|---|---|---|---|
Depression | 61.2 | 6.4 | 1 | |
Exercise | 54.9 | 29.7 | −0.184 ** | 1 |
Fatigue | 24.2 | 6.7 | 0.460 ** | −0.219 ** |
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Calderon, C.; Gustems, M.; Obispo, B.; García-García, T.; Hernández, R.; Fernández-Montes, A.; Jiménez-Fonseca, P. The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer. Curr. Oncol. 2024, 31, 3006-3016. https://doi.org/10.3390/curroncol31060229
Calderon C, Gustems M, Obispo B, García-García T, Hernández R, Fernández-Montes A, Jiménez-Fonseca P. The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer. Current Oncology. 2024; 31(6):3006-3016. https://doi.org/10.3390/curroncol31060229
Chicago/Turabian StyleCalderon, Caterina, Marina Gustems, Berta Obispo, Teresa García-García, Raquel Hernández, Ana Fernández-Montes, and Paula Jiménez-Fonseca. 2024. "The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer" Current Oncology 31, no. 6: 3006-3016. https://doi.org/10.3390/curroncol31060229
APA StyleCalderon, C., Gustems, M., Obispo, B., García-García, T., Hernández, R., Fernández-Montes, A., & Jiménez-Fonseca, P. (2024). The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer. Current Oncology, 31(6), 3006-3016. https://doi.org/10.3390/curroncol31060229