Next Article in Journal
The Experience of Patients with Endocrine Therapy for Breast Cancer: A Patient Journey Map Based on Qualitative Research
Previous Article in Journal
Progress and Challenges in Canada’s Path Toward the Elimination of Cervical Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 31
Issue 10
10.3390/curroncol31100436
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Prognostic Index for Liver Radiation (PILiR)

by
Laura Callan
1,
Haddis Razeghi
2,3,
Natalie Grindrod
2,4,
Stewart Gaede
2,5,
Eugene Wong
2,5,
David Tan
6,
Jason Vickress
2,5,
John Patrick
2 and
Michael Lock
2,7,*
1
BC Cancer-Kelowna, Kelowna, BC V1Y 5L3, Canada
2
Radiation Oncology, London Health Sciences Centre, London, ON N6A 5W9, Canada
3
Faculty of Nursing, Western University, London, ON N6A 3K7, Canada
4
Pathology & Labaratory Medicine, Western University, London, ON N6A 3K7, Canada
5
Department of Physics and Astronomy, Western University, London, ON N6A 3K7, Canada
6
Asian Alliance Radiation & Oncology, Centre for Stereotactic Radiosurgery, Singapore 289891, Singapore
7
Schulich School of Medicine, Western University, London, ON N6A 3K7, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2024, 31(10), 5862-5872; https://doi.org/10.3390/curroncol31100436
Submission received: 20 August 2024 / Revised: 25 September 2024 / Accepted: 27 September 2024 / Published: 29 September 2024
Browse Figures
Versions Notes

Abstract

A Prognostic Index for Liver Radiation (PILiR) for improved patient selection for stereotactic liver-directed radiotherapy (SBRT) was developed. Using a large single-center database, 195 patients treated with SBRT for local control, including 66 with hepatocellular carcinoma (HCC) and 129 with metastatic liver disease, were analyzed. Only patients ineligible for alternative treatments were included. Overall survival was 11.9 months and 9.4 months in the HCC group and metastatic groups, respectively. In the combined dataset, Child–Pugh Score (CPS) (p = 0.002), serum albumin (p = 0.039), and presence of extrahepatic disease (p = 0.012) were significant predictors of early death on multivariable analysis and were included in the PILiR (total score 0 to 5). Median survival was 23.8, 9.1, 4.5, and 2.6 months for patients with 0, 1–2, 3, and 4–5 points, respectively. In the HCC dataset, CPS (p < 0.001) and gross tumor volume (p = 0.013) were predictive of early death. In the metastatic dataset, serum albumin (p < 0.001) and primary disease site (p = 0.003) were predictive of early death. The AUC for the combined, HCC, and metastatic datasets are 0.78, 0.84, and 0.80, respectively. Poor liver function (defined by CPS and serum albumin) and extrahepatic disease were most predictive of early death, providing clinically important expected survival information for patients and caregivers.
Keywords: hepatocellular carcinoma; nomogram; external beam radiotherapy; overall survival; stereotactic body radiotherapy; liver metastasis hepatocellular carcinoma; nomogram; external beam radiotherapy; overall survival; stereotactic body radiotherapy; liver metastasis

Share and Cite

MDPI and ACS Style

Callan, L.; Razeghi, H.; Grindrod, N.; Gaede, S.; Wong, E.; Tan, D.; Vickress, J.; Patrick, J.; Lock, M. Prognostic Index for Liver Radiation (PILiR). Curr. Oncol. 2024, 31, 5862-5872. https://doi.org/10.3390/curroncol31100436

AMA Style

Callan L, Razeghi H, Grindrod N, Gaede S, Wong E, Tan D, Vickress J, Patrick J, Lock M. Prognostic Index for Liver Radiation (PILiR). Current Oncology. 2024; 31(10):5862-5872. https://doi.org/10.3390/curroncol31100436

Chicago/Turabian Style

Callan, Laura, Haddis Razeghi, Natalie Grindrod, Stewart Gaede, Eugene Wong, David Tan, Jason Vickress, John Patrick, and Michael Lock. 2024. "Prognostic Index for Liver Radiation (PILiR)" Current Oncology 31, no. 10: 5862-5872. https://doi.org/10.3390/curroncol31100436

APA Style

Callan, L., Razeghi, H., Grindrod, N., Gaede, S., Wong, E., Tan, D., Vickress, J., Patrick, J., & Lock, M. (2024). Prognostic Index for Liver Radiation (PILiR). Current Oncology, 31(10), 5862-5872. https://doi.org/10.3390/curroncol31100436

Article Metrics

Back to TopTop