2018 February - 29 articles
Human papillomavirus (HPV) is the primary cause of cervical, anal, and other genital cancers, which are preventable through screening and early treatment. [...]
Self-sampling for human papillomavirus (hpv) has the potential to reach marginalized populations that are underserved for cervical cancer screening. [...]
Background: We designed a phase I study of concurrent chemoradiotherapy (CCRT) with docetaxel (D) and cisplatin (C), followed by consolidation DC, for unresectable stage III non-small cell lung cancer (NSCLC). Methods: Patients with histologically pr...
Background: In 2016, everolimus was approved by Health Canada for the treatment of unresectable, locally advanced or metastatic, well-differentiated, non-functional, neuroendocrine tumours (NET) of gastrointestinal (GI) or lung origin in adult patien...
Background: Pediatric survivors of childhood cancer are at increased risk of poor quality of life and social-emotional outcomes following treatment. The relationship between parent psychological distress and child adjustment in pediatric cancer survi...
Background: Across our province, post-radiotherapy (RT) handover notes are sent to family physicians (FPS) after RT. Based on previous FP feedback, we created a revised post-radiotherapy handover note with more information requested by FPS. The purpo...
Background: The Spinal Instability Neoplastic Score (SINS) was developed to identify patients with spinal metastases who may benefit from surgical consultation. We aimed to assess the distribution of SINS in a population-based cohort of patients unde...
Background: The Ottawa Hospital (TOH) defined delay to timely lung cancer care as a system design problem. Recognizing the patient need for an integrated journey and the need for dynamic alignment of providers, TOH used a learning health system (LHS)...
Background: Operating room slowdowns occur at specific intervals in the year as a cost-saving measure. We aim to investigate the impact of these slowdowns on the care of oral cavity cancer patients at a Canadian tertiary care centre. Methods: A total...
Background: The development and approval of both targeted and immune therapies for patients with advanced non-small cell lung cancer (NSCLS) has significantly improved patient survival rates and quality of life. Biomarker testing for patients newly d...
The 2017 annual meeting of the American Society of Hematology took place 9–12 December in Atlanta, Georgia. At the meeting, results from key studies in the treatment of relapsed and refractory mantle cell lymphoma were presented. Of those studies, or...
The 2017 annual meeting of the American Society of Hematology took place 9–12 December in Atlanta, Georgia. At the meeting, the oral presentations included results from key studies on the first-line treatment of chronic lymphocytic leukemia. A series...
In this new era of precision medicine and patient-centred care, the advent of self-sampling in cervical cancer screening is among the most disruptive innovations in cancer control and prevention[...]
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful necrotic ulceration affecting preferentially the lower extremities. Diagnosis is challenging, and a thorough workup (including biopsy) is required. In this case repo...
Merkel cell carcinoma (MCC) is an uncommon malignancy of the skin arising from cells located in the deeper layers of the epidermis called Merkel cells. This malignancy rarely presents as a metastatic disease, and the field is therefore deficient in r...
Objectives: To examine factors that enhance under-screened and never-screened women’s completion of the selfcollection alternative pathway of the Renewed National Cervical Screening Program (NCSP) in Victoria, Australia. Background: With the Australi...
Background: Commencing 1 December 2017, Australia introduced human papillomavirus (HPV)-based cervical screening. As part of this Australian renewed National Cervical Screening Program (NCSP) women who are either never- or under-screened and who refu...
Background: Procarbazine, lomustine, and vincristine (PCV) significantly improve survival outcomes in LGG (low-grade gliomas). Administration of PCV to LGG patients increased tremendously over the past years as it went from 2 patients per year betwee...
The success of cytology (Pap screening) programs is undeniable and has drastically reduced cervical cancer rates in high-income settings where it has been implemented [...]
Background: Crizotinib has shown greater efficacy in clinical trials than chemotherapy in patients with anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC), but little information is available on its use and outcomes in real...
Angiosarcomas of the breast are rare parenchymal malignancies of the chest wall. Surgery is the main treatment modality with chemotherapy and radiotherapy used in case of recurrence. With generally unfavourable prognosis and lack of clear treatment g...
Background: Patients with metastatic non-small-cell lung cancer (NSCLC) experience great pain and stress. Our study aimed to explore the effect of early palliative care on quality of life in patients with NSCLC. Methods: A total of 150 patients were...
Background: No standardized measures specifically assess cancer survivors’ and healthcare providers’ experience of Survivor Care Plans (SCPS). We sought to develop two care plan evaluation (CPE) measures, one for survivors (CPE-S) and one for healthc...
Cervical cancer rates are disproportionately high among women living with the human immunodeficiency virus (WLHIV). Cervical cancer is preventable through HPV screening, regular Pap tests, and early cancer detection. Evidence indicates that HPV and c...
Background: Self-sampling for human papillomavirus (HPV) has the potential to reach marginalized populations that are underserved for cervical cancer screening. However, before implementing an alternative screening strategy such as self-sampling for...
Human papillomavirus (HPV) infection is the cause of anal squamous cell cancer (ASCC) in 80% of cases. Available research has also shown high prevalence of anal HPV infection among men who have sex with men (MSM). However, HPV vaccination is low amon...
Chemotherapy remains the mainstay of treatment for advanced pancreatic ductal adenocarcinoma (PDA). Two randomized trials have demonstrated superiority of the combination regimens FOLFIRINOX (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) a...
Through a “virtual clinic,” we used the electronic medical record to identify and intervene upon patients with chronic lymphocytic leukemia (CLL) who were not current for pneumococcal vaccines. Within 180 days, 100/160 patients (62%) received the rec...
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system that most often affects immunocompromised individuals. It is caused by the reactivation of the John Cunningham virus (JCV), which is found...
