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Analysis the Link between Periodontal Diseases and Alzheimer’s Disease: A Systematic Review
Review

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

1
Emergency Department, Montpellier University Hospital, 34090 Montpellier, France
2
EA 2415, Aide à la Décision pour une Médecine Personnalisée, Université de Montpellier, 34093 Montpellier, France
3
Department of Odontology, Tours University Hospital, 37000 Tours, France
4
Faculty of Dentistry, Nantes University, 44000 Nantes, France
5
EA 75-05 Education, Ethique, Santé, Faculté de Médecine, Université François-Rabelais, 37044 Tours, France
*
Author to whom correspondence should be addressed.
Academic Editor: Florence Carrouel
Int. J. Environ. Res. Public Health 2021, 18(21), 11157; https://doi.org/10.3390/ijerph182111157
Received: 4 October 2021 / Revised: 20 October 2021 / Accepted: 21 October 2021 / Published: 24 October 2021
(This article belongs to the Special Issue Oral Microbiota and Oral Health)
This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms “plaque,” “saliva,” and “mouth” were associated with the search term “oral diseases” and used in combination with the Boolean operator “AND”/“OR”. We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer’s disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future. View Full-Text
Keywords: Alzheimer’s disease; oral microbiota; oral microbiome; mental disorders Alzheimer’s disease; oral microbiota; oral microbiome; mental disorders
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MDPI and ACS Style

Maitre, Y.; Mahalli, R.; Micheneau, P.; Delpierre, A.; Amador, G.; Denis, F. Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review. Int. J. Environ. Res. Public Health 2021, 18, 11157. https://doi.org/10.3390/ijerph182111157

AMA Style

Maitre Y, Mahalli R, Micheneau P, Delpierre A, Amador G, Denis F. Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review. International Journal of Environmental Research and Public Health. 2021; 18(21):11157. https://doi.org/10.3390/ijerph182111157

Chicago/Turabian Style

Maitre, Yoann, Rachid Mahalli, Pierre Micheneau, Alexis Delpierre, Gilles Amador, and Frédéric Denis. 2021. "Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review" International Journal of Environmental Research and Public Health 18, no. 21: 11157. https://doi.org/10.3390/ijerph182111157

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